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The Effects of Testosterone on Hypothalamic and Serum Oxytocin Levels Are Affected by the Estrogen Milieu in Female Rats
https://tokushima-u.repo.nii.ac.jp/records/2013602
https://tokushima-u.repo.nii.ac.jp/records/2013602e6fdc0d3-56ce-491e-97d4-6777d84984be
| 名前 / ファイル | ライセンス | アクション |
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nu_16_15_2533.pdf (953 KB)
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| アイテムタイプ | 文献 / Documents(1) | |||||||||||||||||||||
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| 公開日 | 2025-01-07 | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/nu16152533 | |||||||||||||||||||||
| 関連名称 | 10.3390/nu16152533 | |||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | The Effects of Testosterone on Hypothalamic and Serum Oxytocin Levels Are Affected by the Estrogen Milieu in Female Rats | |||||||||||||||||||||
| 著者 |
Arata, Moeka
× Arata, Moeka
× 田村, 公× 青木, 秀憲× 野口, 拓樹× 武田, 明日香× 湊, 沙希× Yamamoto, Shota
× 木内, 理世× 吉田, 加奈子× 山本, 由理× 加地, 剛
WEKO
276
× 岩佐, 武
WEKO
439
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| 内容記述 | Previous studies have suggested that the effects of androgens on body weight (BW) and appetite are affected by the estrogen milieu in females; however, the mechanism underlying these effects remains unclear. We hypothesized that androgens may affect endogenous oxytocin (OT), which is a hypothalamic anorectic factor, and that these effects of androgens may be altered by the estrogen milieu in females. To investigate this hypothesis, in the present study, we examined the effects of testosterone on peripheral and central OT levels in ovariectomized female rats that did or did not receive estradiol supplementation. Ovariectomized female rats were randomly divided into non-estradiol-supplemented or estradiol-supplemented groups, and half of the rats in each group were concurrently supplemented with testosterone (i.e., rats were divided into four groups, n = 7 per each group). We also measured peripheral and central OT receptor (OTR) gene expression levels. As a result, we found that testosterone increased serum and hypothalamic OT levels and OT receptor mRNA levels in non-estradiol-supplemented rats, whereas it had no effects on these factors in estradiol-supplemented rats. In addition, testosterone reduced food intake, BW gain, and fat weight in non-estradiol-supplemented rats, whereas it did not have any effects on BW, appetite, or fat weight in estradiol-supplemented rats. These findings indicate that the effects of androgens on OT may be affected by the estrogen milieu, and elevated OT levels may be related to the blunting of appetite and prevention of obesity under estrogen-deficient conditions. | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | oxytocin | |||||||||||||||||||||
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| 主題 | estrogen | |||||||||||||||||||||
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| 主題 | androgen | |||||||||||||||||||||
| 書誌情報 |
en : Nutrients 巻 16, 号 15, p. 2533, 発行日 2024-08-02 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 20726643 | |||||||||||||||||||||
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| 出版者 | MDPI | |||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||
| 権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||
| EID | ||||||||||||||||||||||
| 識別子 | 417199 | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
