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Effect of halloysite nanotubes on poloxamer 407-containing calcium phosphate cement for bone repair applications
https://tokushima-u.repo.nii.ac.jp/records/2013713
https://tokushima-u.repo.nii.ac.jp/records/201371311592438-c99b-4f34-95d0-899817146bf9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ceramint_51_18-A_24493.pdf (941 KB)
Download is available from 2027/3/11.
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| Item type | 文献 / Documents(1) | |||||||||||||||||||
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| 公開日 | 2025-12-22 | |||||||||||||||||||
| アクセス権 | ||||||||||||||||||||
| アクセス権 | embargoed access | |||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.ceramint.2025.03.132 | |||||||||||||||||||
| 関連名称 | 10.1016/j.ceramint.2025.03.132 | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Effect of halloysite nanotubes on poloxamer 407-containing calcium phosphate cement for bone repair applications | |||||||||||||||||||
| 著者 |
Kim, Yeeun
× Kim, Yeeun
× 関根, 一光
WEKO
264
× 浜田, 賢一
WEKO
1670
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| 抄録 | ||||||||||||||||||||
| 内容記述 | Owing to the associated biocompatibility, bioactivity, and osteoconductivity, calcium phosphate cements (CPCs) are widely used for bone repair and augmentation. Despite these advantages, commercially available CPCs often exhibit insufficient strength and injectability for clinical applications. In this study, we aimed to address these limitations by incorporating halloysite nanotubes (HNTs) and poloxamer 407 into CPCs. HNTs, known for their high mechanical strength, modulus, specific surface area, and aspect ratio, were added to improve the mechanical properties of the CPCs. To enhance injectability and minimize leakage from the bone defects, poloxamer 407 was incorporated into the CPCs. The incorporation of HNTs significantly enhanced the compressive strength of the cement, achieving a maximum improvement of 6.8 MPa, which corresponds to a 16.9% increase. Injectability decreased over time for all pastes during the poloxamer 407 sol-gel transition. HNT incorporation did not negatively affect cell viability or induce cytotoxicity, and enhanced cell adhesion and spreading were observed on the CPC surfaces, as demonstrated by in vitro studies using MC3T3-E1 cells. Alkaline phosphatase activity assays indicated improved osteogenic differentiation with HNTs. These results suggest that incorporating up to 3 wt% HNTs into CPCs optimizes their mechanical properties and biological performance, making them suitable for load-bearing applications in bone tissue engineering. Nevertheless, future in vivo studies are necessary to validate these findings and establish the clinical utility of HNT-reinforced CPCs incorporating poloxamer 407. | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Calcium phosphate cement | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Halloysite nanotubes | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Poloxamer 407 | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Mechanical properties | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Biocompatibility | |||||||||||||||||||
| 書誌情報 |
en : Ceramics International 巻 51, 号 18-A, p. 24493-24501, 発行日 2025-03-11 |
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 02728842 | |||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 18733956 | |||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA10622625 | |||||||||||||||||||
| 収録物ID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA11523301 | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||||
| 権利情報 | ||||||||||||||||||||
| 権利情報 | © 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||
| EID | ||||||||||||||||||||
| 識別子 | 419705 | |||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||
