| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2026-03-13 |
| アクセス権 |
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アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1007/s00411-025-01146-y |
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関連名称 |
10.1007/s00411-025-01146-y |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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タイトル |
Sodium orthovanadate alleviates lethal effect of total-body irradiation in mice without impairing recovery of male reproductive function |
| タイトル別表記 |
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その他のタイトル |
Sodium orthovanadate alleviates lethal effect of total body irradiation in mice without impairing recovery of male reproductive function |
| 著者 |
西山, 祐一
Sonoyama, Yuichiro
Wang, Bing
Ghosh, Sharmila
Krishnan P.V., Sharath
Sasatani, Megumi
Shimokawa, Takashi
Aoki, Shin
森田, 明典
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| 抄録 |
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内容記述 |
Sodium orthovanadate (vanadate), a potent inhibitor of p53, has been shown in earlier work to alleviate total-body irradiation (TBI)-induced hematopoietic syndrome. However, as p53 plays a crucial role in normal spermatogenesis, its suppression may raise concerns about potential adverse effects on male reproductive function. In this study, we investigated whether vanadate exacerbates impairment of male fertility when administered for hematopoietic protection under TBI conditions. Trp53 wild-type male ICR mice received a single intraperitoneal injection of vanadate or vehicle, followed by exposure to 6 Gy-TBI, corresponding to a testicular dose of 4.8 Gy. This radiation dose is sufficient to induce hematopoietic syndrome and temporary infertility. Spermatogenic function was assessed by analyzing testicular haploid cell populations and sperm morphology. Fertility recovery was evaluated through mating tests with virgin females, and transgenerational outcomes were assessed by analyzing litter size, fetal body weight, and implantation numbers. Our findings demonstrate that vanadate effectively rescued survival of irradiated animals under conditions known to induce the hematopoietic syndrome, without adversely affecting spermatogenesis. On the contrary, vanadate appeared to promote recovery from temporary infertility, likely through partial suppression of p53 accumulation and Bbc3 expression. This effect was more pronounced in Trp53 heterozygous mice, particularly in those irradiated at a young age. Importantly, the offspring derived from vanadate treated males with recovered fertility exhibited normal development, at least in terms of morphology. Taken together, vanadate confers hematopoietic protection under TBI without compromising, and possibly even supporting, male reproductive recovery. These findings suggest its potential for clinical use with low risk to male fertility. |
| キーワード |
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主題 |
Vanadate |
| キーワード |
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主題 |
p53 inhibitor |
| キーワード |
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主題 |
Radiation-induced infertility |
| キーワード |
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主題 |
Spermatogenesis |
| キーワード |
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主題 |
Transgenerational effect |
| 書誌情報 |
en : Radiation and Environmental Biophysics
巻 64,
号 4,
p. 657-667,
発行日 2025-09-10
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
14322099 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0301634X |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00800192 |
| 出版者 |
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出版者 |
Springer Nature |
| 備考 |
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|
値 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00411-025-01146-y |
| EID |
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識別子 |
459146 |
| 言語 |
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言語 |
eng |
reb_64_4_657.pdf (2.8 MB)
