| Item type |
文献 / Documents(1) |
| 公開日 |
2024-09-05 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3164/jcbn.23-76 |
|
|
関連名称 |
10.3164/jcbn.23-76 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-L1 expression level reflects tumor resistance |
| 著者 |
Yamamoto, Mako
田中, 祐子
Takeda, Risako
中本, 晶子
中本, 真理子
Yagita, Hideo
酒井, 徹
|
| 抄録 |
|
|
内容記述 |
Immune checkpoint therapy has been shown to be an effective therapy for many types of tumors. Much attention has been paid to the development of an effector target would be helpful for immune checkpoint therapy. Genistein has been shown to have an anti-tumor effect both in vitro and in vivo. In this study, we examined the effect of genistein on immune checkpoint blockade therapy against B16F1 melanoma tumors. Mice treated with genistein or anti-programmed death (PD)-1 antibody showed a significant decrease in tumor growth. However, treatment with genistein had no effect on or attenuated the efficacy of immune checkpoint therapy. The percentages of T cell receptor (TCR)β+CD4+ and TCRβ+CD8+ cells and the concentrations of interferon-γ and tumor necrosis factor-α in tumor tissue were not different among the experimental groups. A significant difference was also not found in microbe composition. Interestingly, a high expression level of PD-ligand (L)1 closely reflected the outcome of therapy by genistein or anti-PD-1 antibody. The study showed that a combination of genistein treatment does not improve the effect of immune blockade therapy. It also showed that a high PD-L1 expression level in tumors is a good prediction maker for the outcome of tumor therapy. |
| キーワード |
|
|
主題 |
genistein |
| キーワード |
|
|
主題 |
tumor |
| キーワード |
|
|
主題 |
immune checkpoint therapy |
| キーワード |
|
|
主題 |
PD-1 |
| キーワード |
|
|
主題 |
PD-L1 |
| 書誌情報 |
en : Journal of Clinical Biochemistry and Nutrition
巻 74,
号 1,
p. 57-62,
発行日 2024
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
18805086 |
| 収録物ID |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
09120009 |
| 出版者 |
|
|
出版者 |
Society for Free Radical Research Japan |
| 権利情報 |
|
|
権利情報 |
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License. |
| EID |
|
|
識別子 |
407842 |
| 言語 |
|
|
言語 |
eng |
jcbn_74_1_57.pdf (534 KB)
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