| Item type |
文献 / Documents(1) |
| 公開日 |
2024-09-05 |
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.amjmed.2023.11.001 |
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|
関連名称 |
10.1016/j.amjmed.2023.11.001 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effect of Periodontal Treatment on Reducing Chronic Inflammation in Systemically Healthy Patients With Periodontal Disease |
| タイトル別表記 |
|
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その他のタイトル |
The Effect of Periodontal Treatment on Chronic Inflammation |
| 著者 |
Matsuda, Shinji
Shintani, Tomoaki
Miyagawa, Tsuyoshi
湯本, 浩通
Komatsu, Yasutaka
Dewake, Nanae
Iwata, Takanori
Nagano, Takatoshi
Morozumi, Toshiya
Goto, Ryoma
Kato, Satsuki
Kitamura, Masahiro
Shin, Kitetsu
Sekino, Satoshi
Yamashita, Akiko
Yamashita, Keiko
Yoshimura, Atsutoshi
Sugaya, Tsutomu
Takashiba, Shogo
Taguchi, Yoichiro
Nemoto, Eiji
Nishi, Hiromi
Mizuno, Noriyoshi
Numabe, Yukihiro
Kawaguchi, Hiroyuki
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| 抄録 |
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内容記述 |
BACKGROUND:We determined the effects and an accurate marker of periodontal treatment on serum interleukin (IL)-6 and high-sensitivity C-reactive protein (HsCRP) levels in systemically healthy individuals with periodontal disease.
METHODS:This multicenter study included systemically healthy individuals with periodontal disease who received initial periodontal treatment and had no periodontal treatment history. Periodontal parameters, including periodontal inflamed surface area, masticatory efficiency, and periodontal disease classification; serum IL-6 and HsCRP levels; and serum immunoglobulin (Ig)G titers against periodontal pathogens were evaluated at baseline and after treatment. Subjects were classified as low or high responders (group) based on periodontal inflamed surface area changes.
RESULTS:There were 153 participants. Only periodontal inflamed surface area changes were markedly different between low and high responders. Periodontal treatment (time point) decreased both serum IL-6 and HsCRP levels. The interaction between group and time point was remarkable only for serum IL-6 levels. Changes in serum immunoglobulin (Ig)G titers against periodontal pathogens were not associated with IL-6 changes in high responders. We analyzed the indirect effect of serum anti-Porphyromonas gingivalis type 2 IgG titer changes using mediation analysis and found no significance. However, the direct effect of group (low or high responder) on IL-6 changes was considerable.
CONCLUSIONS:Periodontal treatment effectively decreased serum IL-6 levels, independent of periodontal pathogen infection, in systemically healthy individuals with periodontal disease. |
| キーワード |
|
|
主題 |
Chronic inflammation |
| キーワード |
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|
主題 |
HsCRP |
| キーワード |
|
|
主題 |
Periodontal inflamed surface area |
| キーワード |
|
|
主題 |
Periodontal pathogens |
| キーワード |
|
|
主題 |
Serum IL-6 |
| キーワード |
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|
主題 |
Systemically healthy patients with periodontal disease |
| 書誌情報 |
en : The American Journal of Medicine
巻 137,
号 3,
p. 273-279.e2,
発行日 2023-11-19
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| 収録物ID |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
00029343 |
| 収録物ID |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
15557162 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00520786 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11522976 |
| 出版者 |
|
|
出版者 |
Elsevier Inc. |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the CC BY-NC-ND license. |
| EID |
|
|
識別子 |
407920 |
| 言語 |
|
|
言語 |
eng |
amjmed_137_3_273.pdf (671 KB)
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