| Item type |
文献 / Documents(1) |
| 公開日 |
2024-09-25 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1111/1753-0407.13486 |
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関連名称 |
10.1111/1753-0407.13486 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Evaluation of changes in glycemic control and diabetic complications over time and factors associated with the progression of diabetic complications in Japanese patients with juvenile-onset type 1 diabetes mellitus |
| 著者 |
Masuda, Takafumi
Katakami, Naoto
Watanabe, Hirotaka
Taya, Naohiro
Miyashita, Kazuyuki
Takahara, Mitsuyoshi
Kato, Ken
黒田, 暁生
松久, 宗英
Shimomura, Iichiro
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| 抄録 |
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内容記述 |
Background: This study aimed to evaluate the changes in glycemic control and diabetic complications over time in Japanese patients with juvenile-onset type 1 diabetes mellitus and to clarify the factors associated with the progression of diabetic complications.
Methods: We tracked 129 patients with type 1 diabetes mellitus (21.8 ± 4.1 years old [mean ± SD] with a diabetes duration of 12.6 ± 5.7 years) for up to 19 years and analyzed data on glycated hemoglobin (HbA1c) and indicators related to the severity of diabetic complications (estimated glomerular filtration rate [eGFR], urinary albumin excretion rate [UAE], carotid intima-media thickness [CIMT], and brachial-ankle pulse wave velocity [baPWV]) using linear mixed model and decision tree analysis.
Results: Although the HbA1c and UAE levels improved over time, the eGFR, CIMT, and baPWV worsened. Decision tree analysis showed that HbA1c and the glycoalbumin/HbA1c ratio for eGFR; HbA1c and systolic blood pressure for UAE; low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio, glycoalbumin/HbA1c ratio, and body mass index (BMI) for CIMT; and HbA1c for baPWV were associated factors.
Conclusions: In this retrospective observational study, glycemic control and albuminuria improved; however, renal function and arteriosclerosis worsened over time. HbA1c levels, glycemic excursion, and blood pressure are associated with nephropathy progression. HbA1c levels, glycemic excursion, lipid levels, and BMI are associated with the progression of atherosclerosis. |
| キーワード |
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主題 |
atherosclerosis |
| キーワード |
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|
主題 |
diabetic nephropathy |
| キーワード |
|
|
主題 |
glycemic control |
| キーワード |
|
|
主題 |
juvenile-onset diabetes mellitus |
| キーワード |
|
|
主題 |
type 1 diabetes mellitus |
| 書誌情報 |
en : Journal of Diabetes
巻 16,
号 2,
p. e13486,
発行日 2023-10-18
|
| 収録物ID |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
17530407 |
| 収録物ID |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
17530393 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12488308 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12802796 |
| 出版者 |
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|
出版者 |
John Wiley & Sons Australia |
| 出版者 |
|
|
出版者 |
Ruijin Hospital, Shanghai Jiaotong University School of Medicine |
| 権利情報 |
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|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
408899 |
| 言語 |
|
|
言語 |
eng |
jd_16_2_e13486.pdf (1.1 MB)
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