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Identification of an HLA-A2-Restricted Epitope Peptide Derived from Hypoxia-Inducible Protein 2 (HIG2)
https://tokushima-u.repo.nii.ac.jp/records/2000091
https://tokushima-u.repo.nii.ac.jp/records/20000914fcc6071-ce16-4e32-bb5f-05bd6489816d
| 名前 / ファイル | ライセンス | アクション |
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pone_9_1_e85267.pdf (717 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||||||||||
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| 公開日 | 2024-09-20 | |||||||||||||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0085267 | |||||||||||||||||||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0085267 | |||||||||||||||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||||||
| タイトル | Identification of an HLA-A2-Restricted Epitope Peptide Derived from Hypoxia-Inducible Protein 2 (HIG2) | |||||||||||||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||||||||||||
| その他のタイトル | Identification of HLA-A2-Restricted HIG2 Peptide | |||||||||||||||||||||||||||||||||||||
| 著者 |
Yoshimura, Sachiko
× Yoshimura, Sachiko
× Tsunoda, Takuya
× Osawa, Ryuji
× Harada, Makiko
× Watanabe, Tomohisa
× Hikichi, Tetsuro
× Katsuda, Masahiro
× Miyazawa, Motoki
× Tani, Masaji
× Iwahashi, Makoto
× Takeda, Kazuyoshi
× 片桐, 豊雅
WEKO
316
× Nakamura, Yusuke
× Yamaue, Hiroki
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| 抄録 | ||||||||||||||||||||||||||||||||||||||
| 内容記述 | We herein report the identification of an HLA-A2 supertype-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2), which is known to be a diagnostic marker and a potential therapeutic target for renal cell carcinoma. Among several candidate peptides predicted by the HLA-binding prediction algorithm, HIG2-9-4 peptide (VLNLYLLGV) was able to effectively induce peptide-specific cytotoxic T lymphocytes (CTLs). The established HIG2-9-4 peptide-specific CTL clone produced interferon-γ (IFN-γ) in response to HIG2-9-4 peptide-pulsed HLA-A*02:01-positive cells, as well as to cells in which HLA-A*02:01 and HIG2 were exogenously introduced. Moreover, the HIG2-9-4 peptide-specific CTL clone exerted cytotoxic activity against HIG2-expressing HLA-A*02:01-positive renal cancer cells, thus suggesting that the HIG2-9-4 peptide is naturally presented on HLA-A*02:01 of HIG-2-expressing cancer cells and is recognized by CTLs. Furthermore, we found that the HIG2-9-4 peptide could also induce CTLs under HLA-A*02:06 restriction. Taken together, these findings indicate that the HIG2-9-4 peptide is a novel HLA-A2 supertype-restricted epitope peptide that could be useful for peptide-based immunotherapy against cancer cells with HIG2 expression. | |||||||||||||||||||||||||||||||||||||
| 書誌情報 |
en : PLOS ONE 巻 9, 号 1, p. e85267, 発行日 2014-01-08 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||||||||||||||
| 収録物識別子 | 19326203 | |||||||||||||||||||||||||||||||||||||
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| 出版者 | PLOS | |||||||||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||||||||||||||||||||
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| 識別子 | 282101 | |||||||||||||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||||||||||||
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Yoshimura, Sachiko, Tsunoda, Takuya, Osawa, Ryuji, Harada, Makiko, Watanabe, Tomohisa, Hikichi, Tetsuro, Katsuda, Masahiro, Miyazawa, Motoki, Tani, Masaji, Iwahashi, Makoto, Takeda, Kazuyoshi, 片桐, 豊雅, Nakamura, Yusuke, Yamaue, Hiroki, 2014, Identification of an HLA-A2-Restricted Epitope Peptide Derived from Hypoxia-Inducible Protein 2 (HIG2): PLOS, e85267– p.
