| Item type |
文献 / Documents(1) |
| 公開日 |
2024-10-15 |
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| item_1722929371688 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2188/jea.JE20220341 |
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言語 |
ja |
|
|
関連名称 |
10.2188/jea.JE20220341 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
GWAS of Folate Metabolism With Gene–environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese : The J-MICC Study |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
GWAS of Folate Metabolism in Japanese |
|
言語 |
en |
| 著者 |
Tsukamoto, Mineko
Hishida, Asahi
Tamura, Takashi
Nagayoshi, Mako
Okada, Rieko
Kubo, Yoko
Kato, Yasufumi
Hamajima, Nobuyuki
Nishida, Yuichiro
Shimanoe, Chisato
Ibusuki, Rie
Shibuya, Kenichi
Takashima, Naoyuki
Nakamura, Yasuyuki
Kusakabe, Miho
Nakamura, Yohko
Koyanagi, Yuriko N.
Oze, Isao
Nishiyama, Takeshi
Suzuki, Sadao
Watanabe, Isao
Matsui, Daisuke
Otonari, Jun
Ikezaki, Hiroaki
(勝浦)釜野, 桜子
有澤, 孝吉
Kuriki, Kiyonori
Nakatochi, Masahiro
Momozawa, Yukihide
Takeuchi, Kenji
Wakai, Kenji
Matsuo, Keitaro
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: The present genome-wide association study (GWAS) aimed to reveal the genetic loci associated with folate metabolites, as well as to detect related gene–environment interactions in Japanese.
Methods: We conducted the GWAS of plasma homocysteine (Hcy), folic acid (FA), and vitamin B12 (VB12) levels in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study participants who joined from 2005 to 2012, and also estimated gene–environment interactions. In the replication phase, we used data from the Yakumo Study conducted in 2009. In the discovery phase, data of 2,263 participants from four independent study sites of the J-MICC Study were analyzed. In the replication phase, data of 573 participants from the Yakumo Study were analyzed.
Results: For Hcy, MTHFR locus on chr 1, NOX4 on chr 11, CHMP1A on chr 16, and DPEP1 on chr 16 reached genome-wide significance (P < 5 × 10−8). MTHFR also associated with FA, and FUT2 on chr 19 associated with VB12. We investigated gene-environment interactions in both studies and found significant interactions between MTHFR C677T and ever drinking, current drinking, and physical activity >33% on Hcy (β = 0.039, 0.038 and −0.054, P = 0.018, 0.021 and <0.001, respectively) and the interaction of MTHFR C677T with ever drinking on FA (β = 0.033, P = 0.048).
Conclusion: The present GWAS revealed the folate metabolism-associated genetic loci and gene–environment interactions with drinking and physical activity in Japanese, suggesting the possibility of future personalized cardiovascular disease prevention. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
genome-wide association study |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
folate metabolism |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gene–environment interaction |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cardiovascular disease prevention |
| bibliographic_information |
en : Journal of Epidemiology
巻 34,
号 5,
p. 228-237,
発行日 2024-05-05
|
| 収録物ID |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
13499092 |
| 収録物ID |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
09175040 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10952696 |
| 出版者 |
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|
出版者 |
Japan Epidemiological Association |
|
言語 |
en |
| item_10001_rights_15 |
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|
言語 |
en |
|
権利情報 |
This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| item_1723180141928 |
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|
識別子 |
399162 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jepide_34_5_228.pdf (2.4 MB)
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