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A Meta-Analysis of PTGS1 and PTGS2 Polymorphisms and NSAID Intake on the Risk of Developing Cancer
https://tokushima-u.repo.nii.ac.jp/records/2000108
https://tokushima-u.repo.nii.ac.jp/records/20001080276293c-bf1d-40e5-add3-9a1a0ff6d83c
名前 / ファイル | ライセンス | アクション |
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Item type | 文献 / Documents(1) | |||||||||||||||||||
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公開日 | 2024-09-26 | |||||||||||||||||||
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アクセス権 | open access | |||||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
資源タイプ | journal article | |||||||||||||||||||
出版社版DOI | ||||||||||||||||||||
関連識別子 | https://doi.org/10.1371/journal.pone.0071126 | |||||||||||||||||||
関連名称 | 10.1371/journal.pone.0071126 | |||||||||||||||||||
出版タイプ | ||||||||||||||||||||
出版タイプ | VoR | |||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
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タイトル | A Meta-Analysis of PTGS1 and PTGS2 Polymorphisms and NSAID Intake on the Risk of Developing Cancer | |||||||||||||||||||
タイトル別表記 | ||||||||||||||||||||
その他のタイトル | PTGS Polymorphisms and NSAIDs on Cancer Risk | |||||||||||||||||||
著者 |
Nagao, Mai
× Nagao, Mai
× 佐藤, 陽一
WEKO
1215
× 山内, あい子
WEKO
1147
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内容記述 | Background: Several studies have investigated whether the polymorphisms in the prostaglandin endoperoxide synthase 1 (PTGS1) and PTGS2 genes and nonsteroidal anti-inflammatory drug (NSAID) use are associated with cancer risk; however, those studies have produced mixed results. Therefore, we performed a meta-analysis to evaluate the association between the PTGS1 and PTGS2 polymorphisms and the effect of NSAID use on the risk of developing cancer. Methods: We conducted a comprehensive search in PubMed through March 2012. The odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated using the fixed-effect model or the random-effect model. Results: The database search generated 13 studies that met the inclusion criteria. For PTGS1 rs3842787, NSAID users homozygous for the major allele (CC) had a significantly decreased cancer risk compared with non-NSAID users (OR = 0.73, 95% CI = 0.59–0.89). For PTGS2 rs5275 and rs20417, there were no significant differences between the gene polymorphism and NSAID use on cancer risk among the 8 and 7 studies, respectively. However, in the stratified analysis by the type of cancer or ethnicity population, NSAID users homozygous for the major allele (TT) in rs5275 demonstrated significantly decreased cancer risk compared with non-NSAID users in cancer type not involving colorectal adenoma (OR = 0.70, 95% CI = 0.59–0.83) and among the USA population (OR = 0.67, 95% CI = 0.56–0.82). NSAID users homozygous for the major allele (GG) in rs20417 displayed a significantly decreased cancer risk than non-NSAID users among the US population (OR = 0.72, 95% CI = 0.58–0.88). For the PTGS2 rs689466 and rs2745557 SNPs, there were no significant differences. Conclusion: This meta-analysis suggests that the associations between PTGS polymorphisms and NSAID use on cancer risk may differ with regard to the type of cancer and nationality. |
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書誌情報 |
en : PLOS ONE 巻 8, 号 8, p. e71126, 発行日 2013-08-13 |
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収録物識別子タイプ | EISSN | |||||||||||||||||||
収録物識別子 | 19326203 | |||||||||||||||||||
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出版者 | PLOS | |||||||||||||||||||
権利情報 | ||||||||||||||||||||
権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||
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識別子 | 268344 | |||||||||||||||||||
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言語 | eng |