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A Meta-Analysis of PTGS1 and PTGS2 Polymorphisms and NSAID Intake on the Risk of Developing Cancer

https://tokushima-u.repo.nii.ac.jp/records/2000108
https://tokushima-u.repo.nii.ac.jp/records/2000108
0276293c-bf1d-40e5-add3-9a1a0ff6d83c
名前 / ファイル ライセンス アクション
pone_8_8_e71126.pdf pone_8_8_e71126.pdf (1.8 MB)
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Item type 文献 / Documents(1)
公開日 2024-09-26
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版社版DOI
関連識別子 https://doi.org/10.1371/journal.pone.0071126
関連名称 10.1371/journal.pone.0071126
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
タイトル
タイトル A Meta-Analysis of PTGS1 and PTGS2 Polymorphisms and NSAID Intake on the Risk of Developing Cancer
タイトル別表記
その他のタイトル PTGS Polymorphisms and NSAIDs on Cancer Risk
著者 Nagao, Mai

× Nagao, Mai

en Nagao, Mai

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佐藤, 陽一

× 佐藤, 陽一

WEKO 1215
徳島大学 教育研究者総覧 73845/profile-ja.html
e-Rad_Researcher 10363160

ja 佐藤, 陽一
ISNI

ja-Kana サトウ, ヨウイチ

en Sato, Youichi

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山内, あい子

× 山内, あい子

WEKO 1147
徳島大学 教育研究者総覧 60647/profile-ja.html
e-Rad_Researcher 30122253

ja 山内, あい子
ISNI

ja-Kana ヤマウチ, アイコ

en Yamauchi, Aiko

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内容記述 Background: Several studies have investigated whether the polymorphisms in the prostaglandin endoperoxide synthase 1 (PTGS1) and PTGS2 genes and nonsteroidal anti-inflammatory drug (NSAID) use are associated with cancer risk; however, those studies have produced mixed results. Therefore, we performed a meta-analysis to evaluate the association between the PTGS1 and PTGS2 polymorphisms and the effect of NSAID use on the risk of developing cancer.
Methods: We conducted a comprehensive search in PubMed through March 2012. The odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated using the fixed-effect model or the random-effect model.
Results: The database search generated 13 studies that met the inclusion criteria. For PTGS1 rs3842787, NSAID users homozygous for the major allele (CC) had a significantly decreased cancer risk compared with non-NSAID users (OR = 0.73, 95% CI = 0.59–0.89). For PTGS2 rs5275 and rs20417, there were no significant differences between the gene polymorphism and NSAID use on cancer risk among the 8 and 7 studies, respectively. However, in the stratified analysis by the type of cancer or ethnicity population, NSAID users homozygous for the major allele (TT) in rs5275 demonstrated significantly decreased cancer risk compared with non-NSAID users in cancer type not involving colorectal adenoma (OR = 0.70, 95% CI = 0.59–0.83) and among the USA population (OR = 0.67, 95% CI = 0.56–0.82). NSAID users homozygous for the major allele (GG) in rs20417 displayed a significantly decreased cancer risk than non-NSAID users among the US population (OR = 0.72, 95% CI = 0.58–0.88). For the PTGS2 rs689466 and rs2745557 SNPs, there were no significant differences.
Conclusion: This meta-analysis suggests that the associations between PTGS polymorphisms and NSAID use on cancer risk may differ with regard to the type of cancer and nationality.
書誌情報 en : PLOS ONE

巻 8, 号 8, p. e71126, 発行日 2013-08-13
収録物ID
収録物識別子タイプ EISSN
収録物識別子 19326203
出版者
出版者 PLOS
権利情報
権利情報 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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識別子 268344
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言語 eng
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