| Item type |
文献 / Documents(1) |
| 公開日 |
2024-09-26 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| item_1722929371688 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.jphs.2020.08.004 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.jphs.2020.08.004 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial smooth muscle |
|
言語 |
en |
| 著者 |
高石, 和美
Kinoshita, Hiroyuki
Feng, Guo-Gang
Azma, Toshiharu
川人, 伸次
北畑, 洋
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The role of cytoskeleton dynamics in the oxidative stress toward human vasculature has been unclear. The current study examined whether the cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial smooth muscle. All experiments in the human omental arteries without endothelium or the cultured human coronary artery smooth muscle cells were performed in D-glucose (5.5 mmol/L). The exposure toward D-glucose (20 mmol/L) for 60 min reduced the relaxation or hyperpolarization to an ATP sensitive K+ channel (KATP) opener levcromakalim (10−8 to 3 × 10−6 mol/L and 3 × 10−6 mol/L, respectively). Cytochalasin B and a superoxide inhibitor Tiron, restored them similarly. Cytochalasin B reduced the NADPH oxidase activity, leading to a decrease in superoxide levels of the arteries treated with high D-glucose. Also, cytochalasin B impaired the F-actin constitution and the membrane translocation of an NADPH oxidase subunit p47phox in artery smooth muscle cells treated with high D-glucose. A clinical concentration of cytochalasin B prevented human vascular smooth muscle malfunction via the oxidative stress caused by high glucose. Regulation of the cytoskeleton may be essential to keep the normal vascular function in patients with hyperglycemia. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cytoskeleton |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glucose |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Human |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Oxidative stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Vascular smooth muscle |
| bibliographic_information |
en : Journal of Pharmacological Sciences
巻 144,
号 4,
p. 197-203,
発行日 2020-08-23
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
13478648 |
| 収録物ID |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
13478613 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Japanese Pharmacological Society |
|
言語 |
en |
| item_10001_rights_15 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the CC BY-NC-ND license. |
| item_1723180141928 |
|
|
識別子 |
408151 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jphs_144_4_197.pdf (1 MB)
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