| Item type |
文献 / Documents(1) |
| 公開日 |
2024-10-02 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| item_1722929371688 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1371/journal.pone.0080696 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1371/journal.pone.0080696 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
An Evaluation of Association between a Novel Hippocampal Biology Related SNP (rs7294919) and Schizophrenia |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
rs7294919 and Schizophrenia |
|
言語 |
en |
| 著者 |
Liu, Jiewei
沼田, 周助
Ikeda, Masashi
Watanabe, Yuichiro
Zheng, Xue-bin
Luo, Xiongjian
木下, 誠
Nunokawa, Ayako
Someya, Toshiyuki
大森, 哲郎
Bei, Jin-xin
Chong, Siow-Ann
Lee, Jimmy
Li, Zhiqiang
Liu, Jianjun
Iwata, Nakao
Shi, Yongyong
Li, Ming
Su, Bing
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N = 3) and Japanese (N = 3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p = 0.51 in total samples, odds ratio = 1.02 for allele[C]). The absence of rs7294919’s association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations. |
|
言語 |
en |
| bibliographic_information |
en : PLOS ONE
巻 8,
号 11,
p. e80696,
発行日 2013-11-22
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
19326203 |
| 出版者 |
|
|
出版者 |
PLOS |
|
言語 |
en |
| item_10001_rights_15 |
|
|
言語 |
en |
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| item_1723180141928 |
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|
識別子 |
276115 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_8_11_e80696.pdf (144 KB)
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