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Difference in the Osteoblastic Calcium Signaling Response Between Compression and Stretching Mechanical Stimuli
https://tokushima-u.repo.nii.ac.jp/records/2000119
https://tokushima-u.repo.nii.ac.jp/records/2000119f052aa9d-2aa7-49fd-b3a5-5c7bad2f10df
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jrm_35_5_1135.pdf (4.2 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||
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| 公開日 | 2024-10-09 | |||||||||||||||
| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| item_1722929371688 | ||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.20965/jrm.2023.p1135 | |||||||||||||||
| 言語 | ja | |||||||||||||||
| 関連名称 | 10.20965/jrm.2023.p1135 | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Difference in the Osteoblastic Calcium Signaling Response Between Compression and Stretching Mechanical Stimuli | |||||||||||||||
| 言語 | en | |||||||||||||||
| タイトル別表記 | ||||||||||||||||
| その他のタイトル | Difference in the Osteoblastic Calcium Signaling Response | |||||||||||||||
| 言語 | en | |||||||||||||||
| 著者 |
佐藤, 克也
× 佐藤, 克也
WEKO
367
× Nakahara, Tasuku
× Minami, Kazuyuki
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| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | In orthodontics, various forms of mechanical stimulation induce opposing bone metabolism mechanisms. Bone resorption and bone formation occur in areas of compressive and tensile force action, respectively. The mechanism that causes such a difference in bone metabolism is still unclear. In this study, we investigated the difference in the osteoblastic calcium signaling response between compression and stretching mechanical stimuli. We applied two types of mechanical stimuli to osteoblast-like MC3T3-E1 cells: first microneedle direct indentation onto the cell as compression stimuli, and second stretching stimuli by using originally developed cell stretching MEMS device. Cells were treated with thapsigargin and calcium-free medium to investigate the source of the calcium ion. The results demonstrated variations in the osteoblastic calcium signaling response between the compression and stretching stimuli. The magnitude of an increase in the intracellular calcium ion concentration is much higher in the compression stimuli-applied cell group. Treatment of calcium-free medium nearly suppressed the calcium signaling response to both types of mechanical stimulation. Thapsigargin treatment induced an increase in the magnitude of calcium signaling response to the compression stimuli, while suppressed the slow and sustained increase in the calcium ion concentration in the stretching stimuli-applied cell group. These findings demonstrate the difference in the characteristics of osteoblastic calcium signaling response between compression and stretching mechanical stimuli. | |||||||||||||||
| 言語 | en | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | cell biomechanics | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | MEMS | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | calcium signaling | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | mechanical stimuli | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | osteoblast | |||||||||||||||
| bibliographic_information |
en : Journal of Robotics and Mechatronics 巻 35, 号 5, p. 1135-1142, 発行日 2023-10-20 |
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| 収録物ID | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 09153942 | |||||||||||||||
| 収録物ID | ||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 18838049 | |||||||||||||||
| 収録物ID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA10809998 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Fuji Technology Press | |||||||||||||||
| 言語 | en | |||||||||||||||
| item_10001_rights_15 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NoDerivatives 4.0 InternationalLicense. | |||||||||||||||
| item_1723180141928 | ||||||||||||||||
| 識別子 | 403512 | |||||||||||||||
| 識別子タイプ | URI | |||||||||||||||
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| 言語 | eng | |||||||||||||||
