Role of stromal PD-L1 expression in colorectal liver metastasis

Background and Aim
The outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of immune checkpoint blockade for liver metastasis of various cancer is poor. Here, we investigated the relationship between stromal programmed death-ligand 1 (PD-L1) expression and the prognosis of patients with colorectal cancer liver metastasis (CRLM).
Methods
The present study enrolled 84 CRLM patients who underwent surgery (R0) for CRC. Immunohistochemistry was performed to analyze stromal PD-L1 expression in CRLM.
Results
Stromal PD-L1 was expressed in 52.3% of CRLM samples, which was associated with fewer not optimally resectable metastases (p=0.04). Stromal PD-L1 also tended to associate with a lower tumor grade (p=0.08). Stromal PD-L1-positive patients had longer overall survival (p=0.003). Multivariate analysis identified stromal PD-L1 expression (p=0.008) and poorer differentiation (p<0.001) as independent prognostic indicators. Furthermore, stromal PD-L1 expression was correlated to a high number of tumor-infiltrating lymphocytes (TILs). Stromal PD-L1– and low TIL groups had shorter OS than stromal PD-L1+and high TIL groups (46.6% vs. 81.8%, p=0.05) Stromal PD-L1-positive patients had longer disease-free survival (DFS) (p=0.03) and time to surgical failure (p=0.001). Interestingly, stromal PD-L1 expression was positively related to the desmoplastic subtype (p=0.0002) and inversely related to the replacement subtype of the histological growth pattern (p=0.008).
Conclusions
Stromal PD-L1 expression may be a significant prognostic marker for CRLM.

キーワード

主題

Immune check point

キーワード

主題

Stroma

キーワード

主題

PD-1

書誌情報

en : BMC Cancer

巻 24, p. 97, 発行日 2024-01-17

収録物ID

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EISSN

収録物識別子

14712407

収録物ID

収録物識別子タイプ

NCID

収録物識別子

AA12034763

出版者

BioMed Central

出版者

Springer Nature

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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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406427

言語

eng

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