| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2024-10-03 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0075960 |
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関連名称 |
10.1371/journal.pone.0075960 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Chronic Academic Stress Increases a Group of microRNAs in Peripheral Blood |
| タイトル別表記 |
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その他のタイトル |
Chronic Stress-Responsive microRNAs in Blood |
| 著者 |
Honda, Manami
桑野, 由紀
(勝浦)釜野, 桜子
WEKO
653
e-Rad_Researcher
00612574
| ja |
(勝浦)釜野, 桜子
(勝浦)釜野, 桜子
ISNI
|
| ja-Kana |
(カツウラ)カマノ, サクラコ
(カツウラ)カマノ, サクラコ
|
| en |
Katsuura-Kamano, Sakurako
Katsuura-Kamano, Sakurako
|
Search repository
Kamezaki, Yoshiko
Fujita, Kinuyo
Akaike, Yoko
Kano, Shizuka
西田, 憲生
増田, 清士
WEKO
272
e-Rad_Researcher
00457318
| ja |
増田, 清士
増田, 清士
ISNI
|
| ja-Kana |
マスダ, キヨシ
マスダ, キヨシ
|
| en |
Masuda, Kiyoshi
Masuda, Kiyoshi
|
Search repository
六反, 一仁
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| 抄録 |
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内容記述 |
MicroRNAs (miRNAs) play key roles in regulation of cellular processes in response to changes in environment. In this study, we examined alterations in miRNA profiles in peripheral blood from 25 male medical students two months and two days before the National Examination for Medical Practitioners. Blood obtained one month after the examination were used as baseline controls. Levels of seven miRNAs (miR-16, -20b, -26b, -29a, -126, -144 and -144*) were significantly elevated during the pre-examination period in association with significant down-regulation of their target mRNAs (WNT4, CCM2, MAK, and FGFR1 mRNAs) two days before the examination. State anxiety assessed two months before the examination was positively and negatively correlated with miR-16 and its target WNT4 mRNA levels, respectively. Fold changes in miR-16 levels from two days before to one month after the examination were inversely correlated with those in WNT4 mRNA levels over the same time points. We also confirmed the interaction between miR-16 and WNT4 3′UTR in HEK293T cells overexpressing FLAG-tagged WNT4 3′UTR and miR-16. Thus, a distinct group of miRNAs in periheral blood may participate in the integrated response to chronic academic stress in healthy young men. |
| 書誌情報 |
en : PLOS ONE
巻 8,
号 10,
p. e75960,
発行日 2013-10-09
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
19326203 |
| 出版者 |
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出版者 |
PLOS |
| 権利情報 |
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権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
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識別子 |
283536 |
| 言語 |
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言語 |
eng |
pone_8_10_e75960.pdf (574 KB)
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