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PhoB Regulates the Survival of Bacteroides fragilis in Peritoneal Abscesses
https://tokushima-u.repo.nii.ac.jp/records/2000186
https://tokushima-u.repo.nii.ac.jp/records/20001866177e1b0-4eb8-463d-a27a-33b3c0a201e6
| 名前 / ファイル | ライセンス | アクション |
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pone_8_1_e53829.pdf (690 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||
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| 公開日 | 2024-10-08 | |||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0053829 | |||||||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0053829 | |||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | PhoB Regulates the Survival of Bacteroides fragilis in Peritoneal Abscesses | |||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||
| その他のタイトル | Pho B in Bacteroides fragilis | |||||||||||||||||||||||||
| 著者 |
Wakimoto, Shin
× Wakimoto, Shin
× Nakayama-Imaohji, Haruyuki
× Ichimura, Minoru
× Morita, Hidetoshi
× Hirakawa, Hideki
× Hayashi, Tetsuya
× 安友, 康二
WEKO
1521
× Kuwahara, Tomomi
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| 抄録 | ||||||||||||||||||||||||||
| 内容記述 | In response to phosphate limitation, bacteria employ the Pho regulon, a specific regulatory network for phosphate acquisition. The two-component signal transduction system of PhoRB plays a crucial role in the induction of Pho regulon genes, leading to the adaptation to phosphate starvation. Herein, we identified the PhoRB system in Bacteroides fragilis, a commensal gut bacterium, and evaluated its role in gut colonization and survival in peritoneal abscesses. BF1575 and BF1576 encoded PhoR (sensor histidine kinase) and PhoB (response regulator) in the sequenced B. fragilis strain YCH46, respectively. Transcriptome analysis revealed that deletion of phoB affected the expression of 585 genes (more than 4-fold change) in B. fragilis, which included genes for stress response (chaperons and heat shock proteins), virulence (capsular polysaccharide biosynthesis) and phosphate metabolism. Deletion of phoB reduced the ability of the bacterium to persist in peritoneal abscesses induced by an intra-abdominal challenge of B. fragilis. Furthermore, PhoB was necessary for survival of this anaerobe in peritoneal abscesses but not for in vitro growth in rich media or in intestinal colonization. These results indicate that PhoB plays an important role in the survival of B. fragilis under stressful extraintestinal conditions. | |||||||||||||||||||||||||
| 書誌情報 |
en : PLOS ONE 巻 8, 号 1, p. e53829, 発行日 2013-01-15 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||
| 収録物識別子 | 19326203 | |||||||||||||||||||||||||
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| 出版者 | PLOS | |||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||||||||
| EID | ||||||||||||||||||||||||||
| 識別子 | 282661 | |||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||
