| Item type |
文献 / Documents(1) |
| 公開日 |
2024-10-08 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| item_1722929371688 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1371/journal.pone.0060453 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1371/journal.pone.0060453 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Potential Roles of CCR5+ CCR6+ Dendritic Cells Induced by Nasal Ovalbumin plus Flt3 Ligand Expressing Adenovirus for Mucosal IgA Responses |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
The Molecular Basis for DC-Mediated Nasal Immunity |
|
言語 |
en |
| 著者 |
Fukuyama, Yoshiko
Tokuhara, Daisuke
Sekine, Shinichi
Aso, Kazuyoshi
片岡, 宏介
Davydova, Julia
Yamamoto, Masato
Gilbert, Rebekah S.
Tokuhara, Yuka
Fujihashi, Keiko
Kunisawa, Jun
Yuki, Yoshikazu
Kiyono, Hiroshi
McGhee, Jerry R.
Fujihashi, Kohtaro
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We assessed the role of CCR5+/CCR6+/CD11b+/CD11c+ dendritic cells (DCs) for induction of ovalbumin (OVA)-specific antibody (Ab) responses following mucosal immunization. Mice given nasal OVA plus an adenovirus expressing Flt3 ligand (Ad-FL) showed early expansion of CCR5+/CCR6+/CD11b+/CD11c+ DCs in nasopharyngeal-associated lymphoid tissue (NALT) and cervical lymph nodes (CLNs). Subsequently, this DC subset became resident in submandibular glands (SMGs) and nasal passages (NPs) in response to high levels of CCR-ligands produced in these tissues. CD11b+/CD11c+ DCs were markedly decreased in both CCR5−/− and CCR6−/− mice. Chimera mice reconstituted with bone marrow cells from CD11c-diphtheria toxin receptor (CD11c-DTR) and CCR5−/− or CD11c-DTR and CCR6−/− mice given nasal OVA plus Ad-FL had elevated plasma IgG, but reduced IgA as well as low anti-OVA secretory IgA (SIgA )Ab responses in saliva and nasal washes. These results suggest that CCR5+CCR6+ DCs play an important role in the induction of Ag-specific SIgA Ab responses. |
|
言語 |
en |
| bibliographic_information |
en : PLOS ONE
巻 8,
号 4,
p. e60453,
発行日 2013-04-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
19326203 |
| 出版者 |
|
|
出版者 |
PLOS |
|
言語 |
en |
| item_10001_rights_15 |
|
|
言語 |
en |
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| item_1723180141928 |
|
|
識別子 |
374193 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_8_4_e60453.pdf (1.7 MB)
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