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Human Vascular Smooth Muscle Function and Oxidative Stress Induced by NADPH Oxidase with the Clinical Implications
https://tokushima-u.repo.nii.ac.jp/records/2000199
https://tokushima-u.repo.nii.ac.jp/records/2000199312e0516-2524-4f8c-89cd-eea35346d733
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
cells_10_8_1947.pdf (1.4 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||
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| 公開日 | 2024-10-22 | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/cells10081947 | |||||||||||||||||||||
| 関連名称 | 10.3390/cells10081947 | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Human Vascular Smooth Muscle Function and Oxidative Stress Induced by NADPH Oxidase with the Clinical Implications | |||||||||||||||||||||
| 著者 |
高石, 和美
× 高石, 和美
WEKO
1675
× Kinoshita, Hiroyuki
× Kawashima, Shingo
× 川人, 伸次
WEKO
1644
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| 内容記述 | Among reactive oxygen species, superoxide mediates the critical vascular redox signaling, resulting in the regulation of the human cardiovascular system. The reduced form of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) is the source of superoxide and relates to the crucial intracellular pathology and physiology of vascular smooth muscle cells, including contraction, proliferation, apoptosis, and inflammatory response. Human vascular smooth muscle cells express NOX1, 2, 4, and 5 in physiological and pathological conditions, and those enzymes play roles in most cardiovascular disorders caused by hypertension, diabetes, inflammation, and arteriosclerosis. Various physiologically active substances, including angiotensin II, stimulate NOX via the cytosolic subunits’ translocation toward the vascular smooth muscle cell membrane. As we have shown, some pathological stimuli such as high glucose augment the enzymatic activity mediated by the phosphatidylinositol 3-kinase-Akt pathway, resulting in the membrane translocation of cytosolic subunits of NOXs. This review highlights and details the roles of human vascular smooth muscle NOXs in the pathophysiology and clinical aspects. The regulation of the enzyme expressed in the vascular smooth muscle cells may lead to the prevention and treatment of human cardiovascular diseases. | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | human vascular smooth muscle | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | NADPH oxidase | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | oxidase stress | |||||||||||||||||||||
| 書誌情報 |
en : Cells 巻 10, 号 8, p. 1947, 発行日 2021-07-31 |
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| 収録物ID | ||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 20734409 | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | MDPI | |||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||
| 権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | |||||||||||||||||||||
| EID | ||||||||||||||||||||||
| 識別子 | 408150 | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
