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Antiallergic Activity of 3-O-Dodecyl-L-ascorbic Acid
https://tokushima-u.repo.nii.ac.jp/records/2000201
https://tokushima-u.repo.nii.ac.jp/records/20002012a2599d2-3957-4ad5-952e-ed3421d06f58
| 名前 / ファイル | ライセンス | アクション |
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molecules_29_1_69.pdf (2.2 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||
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| 公開日 | 2024-10-22 | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/molecules29010069 | |||||||||||||||||||||||||
| 関連名称 | 10.3390/molecules29010069 | |||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | Antiallergic Activity of 3-O-Dodecyl-L-ascorbic Acid | |||||||||||||||||||||||||
| 著者 |
古賀, 武尊
× 古賀, 武尊× Kawahara, Naoaki
× Aburada, Mei
× Ono, Asako
× Mae, Shiori
× Yoshida, Aina
× Iwaoka, Yuji
× Ito, Hideyuki
× 田井, 章博
WEKO
959
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| 内容記述 | 2-O-Alkyl-L-ascorbic acids and 3-O-alkyl-L-ascorbic acids were synthesized, and their degranulation inhibitory activities were evaluated. Among ascorbic acid derivatives with butyl, octyl, dodecyl, hexadecyl, and octadecyl groups introduced at the C-2 or C-3 positions, an AA derivative with a dodecyl group introduced at the C-3 position, 3-O-dodecyl-L-ascorbic acid (compound 8), showed the strongest inhibitory activity against antigen-stimulated degranulation. Compound 8 also inhibited calcium ionophore-stimulated degranulation. Compound 11, in which the hydroxyl group at the C-6 position of compound 8 was substituted with an amino group, and compound 12, in which the dodecyloxy group at the C-3 position of compound 8 was exchanged with a dodecylamino group, were synthesized, and these derivatives showed weaker inhibitory activity against antigen-stimulated degranulation than that of compound 8. In addition, orally administered compound 8 inhibited passive cutaneous anaphylaxis reactions in mice with a potency equal to that of oxatomide, an antiallergic agent. These results suggest that compound 8 may be a candidate for antiallergic treatment. | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | ascorbic acid derivatives | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | degranulation inhibitory activity | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | passive cutaneous anaphylaxis (PCA) reaction | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | RBL-2H3 cells | |||||||||||||||||||||||||
| 書誌情報 |
en : Molecules 巻 29, 号 1, p. 69, 発行日 2023-12-21 |
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| 収録物ID | ||||||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||
| 収録物識別子 | 14203049 | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | MDPI | |||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||
| 権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | |||||||||||||||||||||||||
| EID | ||||||||||||||||||||||||||
| 識別子 | 404808 | |||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||
