| Item type |
文献 / Documents(1) |
| 公開日 |
2024-10-22 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| item_1722929371688 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/molecules29010069 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/molecules29010069 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Antiallergic Activity of 3-O-Dodecyl-L-ascorbic Acid |
|
言語 |
en |
| 著者 |
古賀, 武尊
Kawahara, Naoaki
Aburada, Mei
Ono, Asako
Mae, Shiori
Yoshida, Aina
Iwaoka, Yuji
Ito, Hideyuki
田井, 章博
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
2-O-Alkyl-L-ascorbic acids and 3-O-alkyl-L-ascorbic acids were synthesized, and their degranulation inhibitory activities were evaluated. Among ascorbic acid derivatives with butyl, octyl, dodecyl, hexadecyl, and octadecyl groups introduced at the C-2 or C-3 positions, an AA derivative with a dodecyl group introduced at the C-3 position, 3-O-dodecyl-L-ascorbic acid (compound 8), showed the strongest inhibitory activity against antigen-stimulated degranulation. Compound 8 also inhibited calcium ionophore-stimulated degranulation. Compound 11, in which the hydroxyl group at the C-6 position of compound 8 was substituted with an amino group, and compound 12, in which the dodecyloxy group at the C-3 position of compound 8 was exchanged with a dodecylamino group, were synthesized, and these derivatives showed weaker inhibitory activity against antigen-stimulated degranulation than that of compound 8. In addition, orally administered compound 8 inhibited passive cutaneous anaphylaxis reactions in mice with a potency equal to that of oxatomide, an antiallergic agent. These results suggest that compound 8 may be a candidate for antiallergic treatment. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ascorbic acid derivatives |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
degranulation inhibitory activity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
passive cutaneous anaphylaxis (PCA) reaction |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
RBL-2H3 cells |
| bibliographic_information |
en : Molecules
巻 29,
号 1,
p. 69,
発行日 2023-12-21
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
14203049 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| item_10001_rights_15 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. |
| item_1723180141928 |
|
|
識別子 |
404808 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
molecules_29_1_69.pdf (2.2 MB)
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