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Nicorandil Attenuates Monocrotaline-Induced Vascular Endothelial Damage and Pulmonary Arterial Hypertension
https://tokushima-u.repo.nii.ac.jp/records/2000204
https://tokushima-u.repo.nii.ac.jp/records/20002047ccb08fa-5658-41ac-aab3-8f705ec9b60a
| 名前 / ファイル | ライセンス | アクション |
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pone_7_3_e33367.pdf (1.4 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||
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| 公開日 | 2024-10-10 | |||||||||||||||||||
| アクセス権 | ||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| item_1722929371688 | ||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0033367 | |||||||||||||||||||
| 言語 | ja | |||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0033367 | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Nicorandil Attenuates Monocrotaline-Induced Vascular Endothelial Damage and Pulmonary Arterial Hypertension | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||
| その他のタイトル | Nicorandil Attenuates Pulmonary Hypertension | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 著者 |
Sahara, Makoto
× Sahara, Makoto
× 佐田, 政隆
WEKO
309
× Morita, Toshihiro
× Hirata, Yasunobu
× Nagai, Ryozo
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Background: An antianginal KATP channel opener nicorandil has various beneficial effects on cardiovascular systems; however, its effects on pulmonary vasculature under pulmonary arterial hypertension (PAH) have not yet been elucidated. Therefore, we attempted to determine whether nicorandil can attenuate monocrotaline (MCT)-induced PAH in rats. Materials and Methods: Sprague-Dawley rats injected intraperitoneally with 60 mg/kg MCT were randomized to receive either vehicle; nicorandil (5.0 mg·kg−1·day−1) alone; or nicorandil as well as either a KATP channel blocker glibenclamide or a nitric oxide synthase (NOS) inhibitor Nω-nitro-L-arginine methyl ester (L-NAME), from immediately or 21 days after MCT injection. Four or five weeks later, right ventricular systolic pressure (RVSP) was measured, and lung tissue was harvested. Also, we evaluated the nicorandil-induced anti-apoptotic effects and activation status of several molecules in cell survival signaling pathway in vitro using human umbilical vein endothelial cells (HUVECs). Results: Four weeks after MCT injection, RVSP was significantly increased in the vehicle-treated group (51.0±4.7 mm Hg), whereas it was attenuated by nicorandil treatment (33.2±3.9 mm Hg; P<0.01). Nicorandil protected pulmonary endothelium from the MCT-induced thromboemboli formation and induction of apoptosis, accompanied with both upregulation of endothelial NOS (eNOS) expression and downregulation of cleaved caspase-3 expression. Late treatment with nicorandil for the established PAH was also effective in suppressing the additional progression of PAH. These beneficial effects of nicorandil were blocked similarly by glibenclamide and L-NAME. Next, HUVECs were incubated in serum-free medium and then exhibited apoptotic morphology, while these changes were significantly attenuated by nicorandil administration. Nicorandil activated the phosphatidylinositol 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) pathways in HUVECs, accompanied with the upregulation of both eNOS and Bcl-2 expression. Conclusions: Nicorandil attenuated MCT-induced vascular endothelial damage and PAH through production of eNOS and anti-apoptotic factors, suggesting that nicorandil might have a promising therapeutic potential for PAH. |
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| 言語 | en | |||||||||||||||||||
| bibliographic_information |
en : PLOS ONE 巻 7, 号 3, p. e33367, 発行日 2012-03-30 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 19326203 | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | PLOS | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| item_10001_rights_15 | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||
| item_1723180141928 | ||||||||||||||||||||
| 識別子 | 246451 | |||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||
