| Item type |
文献 / Documents(1) |
| 公開日 |
2024-10-10 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| item_1722929371688 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1371/journal.pone.0045048 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1371/journal.pone.0045048 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
8-Prenylnaringenin Prevents Disuse Muscle Atrophy |
|
言語 |
en |
| 著者 |
向井, 理恵
Horikawa, Hitomi
Fujikura, Yutaka
Kawamura, Tomoyuki
根本, 尚夫
二川, 健
寺尾, 純二
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake. |
|
言語 |
en |
| bibliographic_information |
en : PLOS ONE
巻 7,
号 9,
p. e45048,
発行日 2012-09-19
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
19326203 |
| 出版者 |
|
|
出版者 |
PLOS |
|
言語 |
en |
| item_10001_rights_15 |
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|
言語 |
en |
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| item_1723180141928 |
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識別子 |
262514 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_7_9_e45048.pdf (509 KB)
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