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A Novel DC Therapy with Manipulation of MKK6 Gene on Nickel Allergy in Mice
| 名前 / ファイル | ライセンス | アクション |
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pone_6_4_e19017.pdf (4 MB)
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| 公開日 | 2024-01-01 | |||||||||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0019017 | |||||||||||||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0019017 | |||||||||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||
| タイトル | A Novel DC Therapy with Manipulation of MKK6 Gene on Nickel Allergy in Mice | |||||||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||||||
| その他のタイトル | DC Therapy for Ni Allergy in Mice | |||||||||||||||||||||||||||||||
| 著者 |
渡邉, 恵
× 渡邉, 恵
WEKO
1260
× 石丸, 直澄
WEKO
1721
× Ashrin, Meinar Nur
× 新垣, 理恵子× 山田, 安希子× 市川, 哲雄
WEKO
1652
× 林, 良夫
WEKO
1659
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| 内容記述 | Background: Although the activation of dermal dendritic cells (DCs) or Langerhans cells (LCs) via p38 mitogen-activated protein kinase (MAPK) plays a crucial role in the pathogenesis of metal allergy, the in vivo molecular mechanisms have not been identified and a possible therapeutic strategy using the control of dermal DCs or LCs has not been established. In this study, we focused on dermal DCs to define the in vivo mechanisms of metal allergy pathogenesis in a mouse nickel (Ni) allergy model. The effects of DC therapy on Ni allergic responses were also investigated. Methods and Finding: The activation of dermal DCs via p38 MAPK triggered a T cell-mediated allergic immune response in this model. In the MAPK signaling cascade in DCs, Ni potently phosphorylated MAP kinase kinase 6 (MKK6) following increased DC activation. Ni-stimulated DCs could prime T cell activation to induce Ni allergy. Interestingly, when MKK6 gene-transfected DCs were transferred into the model mice, a more pronounced allergic reaction was observed. In addition, injection of short interfering (si) RNA targeting the MKK6 gene protected against a hypersensitivity reaction after Ni immunization. The cooperative action between T cell activation and MKK6-mediated DC activation by Ni played an important role in the development of Ni allergy. Conclusions: DC activation by Ni played an important role in the development of Ni allergy. Manipulating the MKK6 gene in DCs may be a good therapeutic strategy for dermal Ni allergy. |
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| 書誌情報 |
en : PLOS ONE 巻 6, 号 4, p. e19017, 発行日 2011-04-22 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||||||||
| 収録物識別子 | 19326203 | |||||||||||||||||||||||||||||||
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| 出版者 | PLOS | |||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||||||||||||||
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| 識別子 | 232332 | |||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||
