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Autism-Associated Gene Expression in Peripheral Leucocytes Commonly Observed between Subjects with Autism and Healthy Women Having Autistic Children
https://tokushima-u.repo.nii.ac.jp/records/2000209
https://tokushima-u.repo.nii.ac.jp/records/20002093f4ce81f-c812-4a89-a5ce-a4c1b3930a00
| 名前 / ファイル | ライセンス | アクション |
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pone_6_9_e24723.pdf (398 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||||
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| 公開日 | 2024-10-10 | |||||||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0024723 | |||||||||||||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0024723 | |||||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||
| タイトル | Autism-Associated Gene Expression in Peripheral Leucocytes Commonly Observed between Subjects with Autism and Healthy Women Having Autistic Children | |||||||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||||||
| その他のタイトル | Autism-Associated Gene Expression Signatures | |||||||||||||||||||||||||||||||
| 著者 |
桑野, 由紀
× 桑野, 由紀
WEKO
392
× Kamio, Yoko
× Kawai, Tomoko
× (勝浦)釜野, 桜子
WEKO
653
× Inada, Naoko
× Takaki, Akiko
× 六反, 一仁
WEKO
1581
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| 内容記述 | Autism spectrum disorder (ASD) is a severe neuropsychiatric disorder which has complex pathobiology with profound influences of genetic factors in its development. Although the numerous autism susceptible genes were identified, the etiology of autism is not fully explained. Using DNA microarray, we examined gene expression profiling in peripheral blood from 21 individuals in each of the four groups; young adults with ASD, age- and gender-matched healthy subjects (ASD control), healthy mothers having children with ASD (asdMO), and asdMO control. There was no blood relationship between ASD and asdMO. Comparing the ASD group with control, 19 genes were found to be significantly changed. These genes were mainly involved in cell morphology, cellular assembly and organization, and nerve system development and function. In addition, the asdMO group possessed a unique gene expression signature shown as significant alterations of protein synthesis despite of their nonautistic diagnostic status. Moreover, an ASD-associated gene expression signature was commonly observed in both individuals with ASD and asdMO. This unique gene expression profiling detected in peripheral leukocytes from affected subjects with ASD and unaffected mothers having ASD children suggest that a genetic predisposition to ASD may be detectable even in peripheral cells. Altered expression of several autism candidate genes such as FMR-1 and MECP2, could be detected in leukocytes. Taken together, these findings suggest that the ASD-associated genes identified in leukocytes are informative to explore the genetic, epigenetic, and environmental background of ASD and might become potential tools to assess the crucial factors related to the clinical onset of the disorder. | |||||||||||||||||||||||||||||||
| 書誌情報 |
en : PLOS ONE 巻 6, 号 9, p. e24723, 発行日 2011-09-15 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||||||||
| 収録物識別子 | 19326203 | |||||||||||||||||||||||||||||||
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| 出版者 | PLOS | |||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||||||||||||||
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| 識別子 | 252174 | |||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||
