| Item type |
文献 / Documents(1) |
| 公開日 |
2024-10-15 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| item_1722929371688 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0066759 |
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言語 |
ja |
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|
関連名称 |
10.1371/journal.pone.0066759 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Dual Involvement of Growth Arrest-Specific Gene 6 in the Early Phase of Human IgA Nephropathy |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Growth Arrest-Specific Gene 6 in IgA Nephropathy |
|
言語 |
en |
| 著者 |
長井, 幸二郎
Miyoshi, Masashi
Kake,Takei
Fukushima, Naoshi
松浦, 元一
柴田, 恵理子
Yamada, Satoshi
Yoshikawa, Kazuhiro
金山, 博臣
布川, 朋也
山口, 邦久
井﨑, 博文
美馬, 晶
安部, 尚子
Araoka, Toshikazu
村上, 太一
Kishi, Fumi
岸, 誠司
冨永, 辰也
Moriya, Tatsumi
安部, 秀斉
土井, 俊夫
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Gas6 is a growth factor that causes proliferation of mesangial cells in the development of glomerulonephritis. Gas6 can bind to three kinds of receptors; Axl, Dtk, and Mer. However, their expression and functions are not entirely clear in the different glomerular cell types. Meanwhile, representative cell cycle regulatory protein p27 has been reported to be expressed in podocytes in normal glomeruli with decreased expression in proliferating glomeruli, which inversely correlated with mesangial proliferation in human IgA nephropathy (IgAN).
Methods: The aim of this study is to clarify Gas6 involvement in the progression of IgAN. Expression of Gas6/Axl/Dtk was examined in 31 biopsy proven IgAN cases. We compared the expression levels with histological severity or clinical data. Moreover, we investigated the expression of Gas6 and its receptors in cultured podocytes.
Results: In 28 of 31 cases, Gas6 was upregulated mainly in podocytes. In the other 3 cases, Gas6 expression was induced in endothelial and mesangial cells, which was similar to animal nephritis models. Among 28 podocyte type cases, the expression level of Gas6 correlated with the mesangial hypercellularity score of IgAN Oxford classification and urine protein excretion. It also inversely correlated with p27 expression in glomeruli. As for the receptors, Axl was mainly expressed in endothelial and mesangial cells, while Dtk was expressed in podocytes. In vitro, Dtk was expressed in cultured murine podocytes, and the expression of p27 was decreased by Gas6 stimulation.
Conclusions: Gas6 was uniquely upregulated in either endothelial/mesangial cells or podocytes in IgAN. The expression pattern can be used as a marker to classify IgAN. Gas6 has a possibility to be involved in not only mesangial proliferation via Axl, but also podocyte injury via Dtk in IgAN. |
|
言語 |
en |
| bibliographic_information |
en : PLOS ONE
巻 8,
号 6,
p. e66759,
発行日 2013-06-24
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
19326203 |
| 出版者 |
|
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出版者 |
PLOS |
|
言語 |
en |
| item_10001_rights_15 |
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|
言語 |
en |
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| item_1723180141928 |
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|
識別子 |
265525 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_8_6_e66759.pdf (1.6 MB)
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