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Oral-Nasopharyngeal Dendritic Cells Mediate T Cell-Independent IgA Class Switching on B-1 B Cells
https://tokushima-u.repo.nii.ac.jp/records/2000219
https://tokushima-u.repo.nii.ac.jp/records/2000219a55f3666-d10c-4f80-bed6-eb39e967945b
| 名前 / ファイル | ライセンス | アクション |
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pone_6_9_e25396.pdf (598 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||
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| 公開日 | 2024-10-16 | |||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0025396 | |||||||||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0025396 | |||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||
| タイトル | Oral-Nasopharyngeal Dendritic Cells Mediate T Cell-Independent IgA Class Switching on B-1 B Cells | |||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||
| その他のタイトル | Mucosal DCs for IgA CSR on B-1 B cells | |||||||||||||||||||||||||||
| 著者 |
片岡, 宏介
× 片岡, 宏介
WEKO
300
× Fujihashi, Keiko
× Terao, Yutaka
× Gilbert, Rebekah S.
× Sekine, Shinichi
× Kobayashi, Ryoki
× Fukuyama, Yoshiko
× Kawabata, Shigetada
× Fujihashi, Kohtaro
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| 抄録 | ||||||||||||||||||||||||||||
| 内容記述 | Native cholera toxin (nCT) as a nasal adjuvant was shown to elicit increased levels of T-independent S-IgA antibody (Ab) responses through IL-5- IL-5 receptor interactions between CD4+ T cells and IgA+ B-1 B cells in murine submandibular glands (SMGs) and nasal passages (NPs). Here, we further investigate whether oral-nasopharyngeal dendritic cells (DCs) play a central role in the induction of B-1 B cell IgA class switch recombination (CSR) for the enhancement of T cell-independent (TI) mucosal S-IgA Ab responses. High expression levels of activation-induced cytidine deaminase, Iα-Cμ circulation transcripts and Iμ-Cα transcripts were seen on B-1 B cells purified from SMGs and NPs of both TCRβ−/− mice and wild-type mice given nasal trinitrophenyl (TNP)-LPS plus nCT, than in the same tissues of mice given nCT or TNP-LPS alone. Further, DCs from SMGs, NPs and NALT of mice given nasal TNP-LPS plus nCT expressed significantly higher levels of a proliferation-inducing ligand (APRIL) than those in mice given TNP-LPS or nCT alone, whereas the B-1 B cells in SMGs and NPs showed elevated levels of transmembrane activator and calcium modulator cyclophilin ligand interactor (TACI) expression. Interestingly, high frequencies of IgA+ B-1 B cells were induced when peritoneal IgA− IgM+ B cells were stimulated with mucosal DCs from mice given nasal TNP-LPS plus nCT. Taken together, these findings show that nasal nCT plays a key role in the enhancement of mucosal DC-mediated TI IgA CSR by B-1 B cells through their interactions with APRIL and TACI. | |||||||||||||||||||||||||||
| 書誌情報 |
en : PLOS ONE 巻 6, 号 9, p. e25396, 発行日 2011-09-29 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||||
| 収録物識別子 | 19326203 | |||||||||||||||||||||||||||
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| 出版者 | PLOS | |||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||||||||||
| EID | ||||||||||||||||||||||||||||
| 識別子 | 374199 | |||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||
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片岡, 宏介, Fujihashi, Keiko, Terao, Yutaka, Gilbert, Rebekah S., Sekine, Shinichi, Kobayashi, Ryoki, Fukuyama, Yoshiko, Kawabata, Shigetada, Fujihashi, Kohtaro, 2011, Oral-Nasopharyngeal Dendritic Cells Mediate T Cell-Independent IgA Class Switching on B-1 B Cells: PLOS, e25396– p.
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