| Item type |
文献 / Documents(1) |
| 公開日 |
2024-10-11 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| item_1722929371688 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0009460 |
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言語 |
ja |
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関連名称 |
10.1371/journal.pone.0009460 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Comprehensive Behavioral Analysis of Calcium/Calmodulin-Dependent Protein Kinase IV Knockout Mice |
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言語 |
en |
| タイトル別表記 |
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その他のタイトル |
Phenotyping of CaMKIV KO Mice |
|
言語 |
en |
| 著者 |
Takao, Keizo
Tanda, Koichi
Nakamura, Kenji
笠原, 二郎
Nakao, Kazuki
Katsuki, Motoya
Nakanishi, Kazuo
Yamasaki, Nobuyuki
Toyama, Keiko
Adachi, Minami
Umeda, Masahiro
Araki, Tsutomu
Fukunaga, Kohji
Kondo, Hisatake
Sakagami, Hiroyuki
Miyakawa, Tsuyoshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that activates the transcription factor CREB, the cyclic AMP-response element binding protein. CREB is a key transcription factor in synaptic plasticity and memory consolidation. To elucidate the behavioral effects of CaMKIV deficiency, we subjected CaMKIV knockout (CaMKIV KO) mice to a battery of behavioral tests. CaMKIV KO had no significant effects on locomotor activity, motor coordination, social interaction, pain sensitivity, prepulse inhibition, attention, or depression-like behavior. Consistent with previous reports, CaMKIV KO mice exhibited impaired retention in a fear conditioning test 28 days after training. In contrast, however, CaMKIV KO mice did not show any testing performance deficits in passive avoidance, one of the most commonly used fear memory paradigms, 28 days after training, suggesting that remote fear memory is intact. CaMKIV KO mice exhibited intact spatial reference memory learning in the Barnes circular maze, and normal spatial working memory in an eight-arm radial maze. CaMKIV KO mice also showed mildly decreased anxiety-like behavior, suggesting that CaMKIV is involved in regulating emotional behavior. These findings indicate that CaMKIV might not be essential for fear memory or spatial memory, although it is possible that the activities of other neural mechanisms or signaling pathways compensate for the CaMKIV deficiency. |
|
言語 |
en |
| bibliographic_information |
en : PLOS ONE
巻 5,
号 3,
p. e9460,
発行日 2010-03-01
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
19326203 |
| 出版者 |
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出版者 |
PLOS |
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言語 |
en |
| item_10001_rights_15 |
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言語 |
en |
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| item_1723180141928 |
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識別子 |
213439 |
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識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_5_3_e9460.pdf (845 KB)
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