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In Situ Patrolling of Regulatory T Cells Is Essential for Protecting Autoimmune Exocrinopathy
https://tokushima-u.repo.nii.ac.jp/records/2000235
https://tokushima-u.repo.nii.ac.jp/records/200023504a50527-8994-4aeb-b743-fc476f0e5431
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
pone_5_1_e8588.pdf (3.3 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||
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| 公開日 | 2024-10-11 | |||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0008588 | |||||||||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0008588 | |||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||
| タイトル | In Situ Patrolling of Regulatory T Cells Is Essential for Protecting Autoimmune Exocrinopathy | |||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||
| その他のタイトル | Patrolling Treg Cells | |||||||||||||||||||||||||||
| 著者 |
石丸, 直澄
× 石丸, 直澄
WEKO
1721
× Nitta, Takeshi
× 新垣, 理恵子× 山田, 安希子× Lipp, Martin
× 高浜, 洋介
WEKO
1519
× 林, 良夫
WEKO
1659
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| 抄録 | ||||||||||||||||||||||||||||
| 内容記述 | Background: Migration of T cells, including regulatory T (Treg) cells, into the secondary lymph organs is critically controlled by chemokines and adhesion molecules. However, the mechanisms by which Treg cells regulate organ-specific autoimmunity via these molecules remain unclear. Although we previously reported autoimmune exocrinopathy resembling Sjögren's syndrome (SS) in the lacrimal and salivary glands from C-C chemokine receptor 7 (CCR7)-deficient mice, it is still unclear whether CCR7 signaling might specifically affect the dynamics and functions of Treg cells in vivo. We therefore investigated the cellular mechanism for suppressive function of Treg cells via CCR7 in autoimmunity using mouse models and human samples. Methods and Findings: Patrolling Treg cells were detected in the exocrine organs such as lacrimal and salivary glands from normal mice that tend to be targets for autoimmunity while the Treg cells were almost undetectable in the exocrine glands of CCR7−/− mice. In addition, we found the significantly increased retention of CD4+CD25+Foxp3+ Treg cells in the lymph nodes of CCR7−/− mice with aging. Although Treg cell egress requires sphingosine 1-phosphate (S1P), chemotactic function to S1P of CCR7−/− Treg cells was impaired compared with that of WT Treg cells. Moreover, the in vivo suppression activity was remarkably diminished in CCR7−/− Treg cells in the model where Treg cells were co-transferred with CCR7−/− CD25-CD4+ T cells into Rag2−/− mice. Finally, confocal analysis showed that CCR7+Treg cells were detectable in normal salivary glands while the number of CCR7+Treg cells was extremely decreased in the tissues from patients with Sjögren's syndrome. Conclusions: These results indicate that CCR7 essentially governs the patrolling functions of Treg cells by controlling the traffic to the exocrine organs for protecting autoimmunity. Characterization of this cellular mechanism could have clinical implications by supporting development of new diagnosis or treatments for the organ-specific autoimmune diseases such as Sjögren's syndrome and clarifying how the local immune system regulates autoimmunity. |
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| 書誌情報 |
en : PLOS ONE 巻 5, 号 1, p. e8588, 発行日 2010-01-05 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||||
| 収録物識別子 | 19326203 | |||||||||||||||||||||||||||
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| 出版者 | PLOS | |||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||||||||||
| EID | ||||||||||||||||||||||||||||
| 識別子 | 203547 | |||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||
