| Item type |
文献 / Documents(1) |
| 公開日 |
2024-11-05 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.7554/eLife.89381 |
|
|
言語 |
ja |
|
|
関連名称 |
10.7554/eLife.89381 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
The reciprocal regulation between mitochondrial-associated membranes and Notch signaling in skeletal muscle atrophy |
|
言語 |
en |
| 著者 |
Ito, Yurika
Yamagata, Mari
Yamamoto, Takuya
平坂, 勝也
二川, 健
Sato, Takahiko
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Skeletal muscle atrophy and the inhibition of muscle regeneration are known to occur as a natural consequence of aging, yet the underlying mechanisms that lead to these processes in atrophic myofibers remain largely unclear. Our research has revealed that the maintenance of proper mitochondrial-associated endoplasmic reticulum membranes (MAM) is vital for preventing skeletal muscle atrophy in microgravity environments. We discovered that the deletion of the mitochondrial fusion protein Mitofusin2 (MFN2), which serves as a tether for MAM, in human induced pluripotent stem (iPS) cells or the reduction of MAM in differentiated myotubes caused by microgravity interfered with myogenic differentiation process and an increased susceptibility to muscle atrophy, as well as the activation of the Notch signaling pathway. The atrophic phenotype of differentiated myotubes in microgravity and the regenerative capacity of Mfn2-deficient muscle stem cells in dystrophic mice were both ameliorated by treatment with the gamma-secretase inhibitor DAPT. Our findings demonstrate how the orchestration of mitochondrial morphology in differentiated myotubes and regenerating muscle stem cells plays a crucial role in regulating Notch signaling through the interaction of MAM. |
|
言語 |
en |
| 書誌情報 |
en : eLife
巻 12,
p. RP89381,
発行日 2023-12-15
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2050084X |
| 出版者 |
|
|
出版者 |
eLife Sciences Publications |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| EID |
|
|
識別子 |
407714 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
elife_12_RP89381.pdf (4.5 MB)
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