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The Kampo Medicine Rokumigan Possesses Antibiofilm, Anti-Inflammatory, and Wound Healing Properties
https://tokushima-u.repo.nii.ac.jp/records/2000253
https://tokushima-u.repo.nii.ac.jp/records/20002538f1cfa75-23dc-4d15-9c4d-2077fbf38c17
| 名前 / ファイル | ライセンス | アクション |
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bmri_2014_436206.pdf (402 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||
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| 公開日 | 2024-10-18 | |||||||||||||||||||
| アクセス権 | ||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1155/2014/436206 | |||||||||||||||||||
| 関連名称 | 10.1155/2014/436206 | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | The Kampo Medicine Rokumigan Possesses Antibiofilm, Anti-Inflammatory, and Wound Healing Properties | |||||||||||||||||||
| 著者 |
Liao, James
× Liao, James
× Azelmat, Jabrane
× Zhao, Lei
× 吉岡, 昌美× 日野出, 大輔
WEKO
1666
× Grenier, Daniel
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| 内容記述 | Periodontal diseases, which are inflammatory diseases of bacterial origin affecting the tooth-supporting tissues, are characterized by inflammation and destruction of gingival connective tissue and alveolar bone, and may lead to tooth loss. The aim of the study was to investigate Rokumigan, a Kampo Japanese traditional medicine made of six different plants, for its capacity to prevent biofilm formation by Fusobacterium nucleatum, to inhibit interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion by mucosal cells, and to promote wound healing in a fibroblast model. Using a microplate colorimetric assay, Rokumigan prevented biofilm formation by F. nucleatum, while it had no effect on bacterial growth. Rokumigan inhibited IL-6 secretion in both epithelial cells and fibroblasts stimulated with lipopolysaccharide. However, it caused no significant inhibition of IL-8 secretion by both cell types. Rokumigan significantly increased proliferation and migration of gingival fibroblasts in a wound healing assay. In conclusion, the Kampo formulation Rokumigan, through suppression of biofilm formation by F. nucleatum, inhibition of IL-6 secretion by gingival epithelial cells and fibroblasts, and promotion of wound healing in a fibroblast model, may have potential application for periodontal diseases. | |||||||||||||||||||
| 書誌情報 |
en : BioMed Research International 巻 2014, p. 436206, 発行日 2014-04-30 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 23146141 | |||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 23146133 | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | Hindawi Publishing Corporation | |||||||||||||||||||
| 権利情報 | ||||||||||||||||||||
| 権利情報 | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||||||||||
| EID | ||||||||||||||||||||
| 識別子 | 292801 | |||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||
