| Item type |
文献 / Documents(1) |
| 公開日 |
2024-10-18 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.1155/2014/436206 |
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|
関連名称 |
10.1155/2014/436206 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
The Kampo Medicine Rokumigan Possesses Antibiofilm, Anti-Inflammatory, and Wound Healing Properties |
| 著者 |
Liao, James
Azelmat, Jabrane
Zhao, Lei
吉岡, 昌美
日野出, 大輔
Grenier, Daniel
|
| 抄録 |
|
|
内容記述 |
Periodontal diseases, which are inflammatory diseases of bacterial origin affecting the tooth-supporting tissues, are characterized by inflammation and destruction of gingival connective tissue and alveolar bone, and may lead to tooth loss. The aim of the study was to investigate Rokumigan, a Kampo Japanese traditional medicine made of six different plants, for its capacity to prevent biofilm formation by Fusobacterium nucleatum, to inhibit interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion by mucosal cells, and to promote wound healing in a fibroblast model. Using a microplate colorimetric assay, Rokumigan prevented biofilm formation by F. nucleatum, while it had no effect on bacterial growth. Rokumigan inhibited IL-6 secretion in both epithelial cells and fibroblasts stimulated with lipopolysaccharide. However, it caused no significant inhibition of IL-8 secretion by both cell types. Rokumigan significantly increased proliferation and migration of gingival fibroblasts in a wound healing assay. In conclusion, the Kampo formulation Rokumigan, through suppression of biofilm formation by F. nucleatum, inhibition of IL-6 secretion by gingival epithelial cells and fibroblasts, and promotion of wound healing in a fibroblast model, may have potential application for periodontal diseases. |
| 書誌情報 |
en : BioMed Research International
巻 2014,
p. 436206,
発行日 2014-04-30
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
23146141 |
| 収録物ID |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
23146133 |
| 出版者 |
|
|
出版者 |
Hindawi Publishing Corporation |
| 権利情報 |
|
|
権利情報 |
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
292801 |
| 言語 |
|
|
言語 |
eng |
bmri_2014_436206.pdf (402 KB)
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