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YIPF3 and YIPF4 regulate autophagic turnover of the Golgi apparatus
https://tokushima-u.repo.nii.ac.jp/records/2000255
https://tokushima-u.repo.nii.ac.jp/records/20002558a348613-97c9-48f6-886f-d3d56d942307
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
embj_43_14_2954.pdf (5.2 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||
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| 公開日 | 2024-11-20 | |||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s44318-024-00131-3 | |||||||||||||||||||||||||||
| 関連名称 | 10.1038/s44318-024-00131-3 | |||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||
| タイトル | YIPF3 and YIPF4 regulate autophagic turnover of the Golgi apparatus | |||||||||||||||||||||||||||
| 著者 |
Kitta, Shinri
× Kitta, Shinri
× Kaminishi, Tatsuya
× Higashi, Momoko
× Shima, Takayuki
× Nishino, Kohei
× Nakamura, Nobuhiro
× 小迫, 英尊
WEKO
301
× Yoshimori, Tamotsu
× Kuma, Akiko
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| 抄録 | ||||||||||||||||||||||||||||
| 内容記述 | The degradation of organelles by autophagy is essential for cellular homeostasis. The Golgi apparatus has recently been demonstrated to be degraded by autophagy, but little is known about how the Golgi is recognized by the forming autophagosome. Using quantitative proteomic analysis and two novel Golgiphagy reporter systems, we found that the five-pass transmembrane Golgi-resident proteins YIPF3 and YIPF4 constitute a Golgiphagy receptor. The interaction of this complex with LC3B, GABARAP, and GABARAPL1 is dependent on a LIR motif within YIPF3 and putative phosphorylation sites immediately upstream; the stability of the complex is governed by YIPF4. Expression of a YIPF3 protein containing a mutated LIR motif caused an elongated Golgi morphology, indicating the importance of Golgi turnover via selective autophagy. The reporter assays reported here may be readily adapted to different experimental contexts to help deepen our understanding of Golgiphagy. | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | Golgiphagy | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | Selective Autophagy | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | Golgi Turnover | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | Organelle Degradation | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | Autophagy Receptor | |||||||||||||||||||||||||||
| 書誌情報 |
en : The EMBO Journal 巻 43, 号 14, p. 2954-2978, 発行日 2024-05-31 |
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| 収録物ID | ||||||||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||||
| 収録物識別子 | 14602075 | |||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||
| 出版者 | EMBO Press | |||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible. | |||||||||||||||||||||||||||
| EID | ||||||||||||||||||||||||||||
| 識別子 | 409520 | |||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||
