| Item type |
文献 / Documents(1) |
| 公開日 |
2024-11-27 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1155/2012/754181 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1155/2012/754181 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Eicosapentaenoic Acid Supplementation Changes Fatty Acid Composition and Corrects Endothelial Dysfunction in Hyperlipidemic Patients |
|
言語 |
en |
| 著者 |
Yamakawa, Ken
島袋, 充生
Higa, Namio
Asahi, Tomohiro
Ohba, Kageyuki
Arasaki, Osamu
Higa, Moritake
Oshiro, Yoshito
Yoshida, Hisashi
Higa, Tohru
Saito, Taro
Ueda, Shinichiro
Masuzaki, Hiroaki
佐田, 政隆
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We investigated the effects of purified eicosapentaenoic acid (EPA) on vascular endothelial function and free fatty acid composition in Japanese hyperlipidemic subjects. In subjects with hyperlipidemia (total cholesterol ≥220 mg/dL and/or triglycerides ≥150 mg/dL), lipid profile and forearm blood flow (FBF) during reactive hyperemia were determined before and 3 months after supplementation with 1800 mg/day EPA. Peak FBF during reactive hyperemia was lower in the hyperlipidemic group than the normolipidemic group. EPA supplementation did not change serum levels of total, HDL, or LDL cholesterol, apolipoproteins, remnant-like particle (RLP) cholesterol, RLP triglycerides, or malondialdehyde-modified LDL cholesterol. EPA supplementation did not change total free fatty acid levels in serum, but changed the fatty acid composition, with increased EPA and decreased linoleic acid, γ-linolenic acid, and dihomo-γ-linolenic acid. EPA supplementation recovered peak FBF after 3 months. Peak FBF recovery was correlated positively with EPA and EPA/arachidonic acid levels and correlated inversely with dihomo-γ-linolenic acid. EPA supplementation restores endothelium-dependent vasodilatation in hyperlipidemic patients despite having no effect on serum cholesterol and triglyceride patterns. These results suggest that EPA supplementation may improve vascular function at least partly via changes in fatty acid composition. |
|
言語 |
en |
| 書誌情報 |
en : Cardiology Research and Practice
巻 2012,
p. 754181,
発行日 2012-12-26
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
20900597 |
| 収録物ID |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
20908016 |
| 出版者 |
|
|
出版者 |
Hindawi Publishing Corporation |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
259114 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
crp_2012_754181.pdf (251 KB)
.png)
