| Item type |
文献 / Documents(1) |
| 公開日 |
2024-11-12 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.heliyon.2023.e19215 |
|
|
関連名称 |
10.1016/j.heliyon.2023.e19215 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Endogenous CCL21-Ser deficiency reduces B16–F10 melanoma growth by enhanced antitumor immunity |
| 著者 |
Fujie, Ryonosuke
Kurowarabe, Kaoru
Yamada, Yuki
Fujiwara, Kakeru
Nakatani, Hayato
Tsutsumi, Kenta
Hayashi, Ryota
Kawahata, Hinami
Miyamoto, Megumi
Ozawa, Madoka
Katakai, Tomoya
高浜, 洋介
大東, いずみ
Hayasaka, Haruko
|
| 抄録 |
|
|
内容記述 |
The chemokine CCL21 regulates immune and cancer cell migration through its receptor CCR7. The Ccl21a gene encodes the isoform CCL21-Ser, predominantly expressed in the thymic medulla and the secondary lymphoid tissues. This study examined the roles of CCL21-Ser in the antitumor immune response in Ccl21a-knockout (KO) mice. The Ccl21a-KO mice showed significantly decreased growth of B16–F10 and YUMM1.7 melanomas and increased growth of MC38 colon cancer, despite no significant difference in LLC lung cancer and EO771 breast cancer. The B16–F10 tumor in Ccl21a-KO mice showed melanoma-specific activated CD8+ T cell and NK cell infiltration and higher Treg counts than wild-type mice. B16–F10 tumors in Ccl21a-KO mice showed a reduction in the positive correlation between the ratio of regulatory T cells (Tregs) to activated CD8+ T cells and tumor weight. In Ccl21a-KO tumor, the intratumoral Tregs showed lower co-inhibitory receptors TIM-3 and TIGIT. Taken together, these results suggest that endogenous CCL21-Ser supports melanoma growth in vivo by maintaining Treg function and suppressing antitumor immunity by CD8+ T cells. |
| キーワード |
|
|
主題 |
Melanoma |
| キーワード |
|
|
主題 |
Chemokine |
| キーワード |
|
|
主題 |
Lymph node |
| キーワード |
|
|
主題 |
CD8 |
| キーワード |
|
|
主題 |
Treg |
| 書誌情報 |
en : Heliyon
巻 9,
号 8,
p. e19215,
発行日 2023-08-19
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24058440 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the CC BY license. |
| EID |
|
|
識別子 |
405840 |
| 言語 |
|
|
言語 |
eng |
heliyon_9_8_e19215.pdf (6.8 MB)
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