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Brimonidine prevents neurodegeneration in a mouse model of normal tension glaucoma
https://tokushima-u.repo.nii.ac.jp/records/2000312
https://tokushima-u.repo.nii.ac.jp/records/2000312433b75df-65b4-4f45-9ee3-6f5dcfe9c812
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
cdd_5_e1341.pdf (1.3 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||
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| 公開日 | 2024-11-18 | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/cddis.2014.306 | |||||||||||||||||||||
| 関連名称 | 10.1038/cddis.2014.306 | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Brimonidine prevents neurodegeneration in a mouse model of normal tension glaucoma | |||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||
| その他のタイトル | Brimonidine prevents normal tension glaucoma | |||||||||||||||||||||
| 著者 |
Semba, K
× Semba, K
× Namekata, K
× Kimura, A
× Harada, C
× 三田村, 佳典
WEKO
426
× Harada, T
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| 内容記述 | Glaucoma is one of the leading causes of irreversible blindness that is characterized by progressive degeneration of optic nerves and retinal ganglion cells (RGCs). In the mammalian retina, excitatory amino-acid carrier 1 (EAAC1) is expressed in neural cells, including RGCs, and the loss of EAAC1 leads to RGC degeneration without elevated intraocular pressure (IOP). Brimonidine (BMD) is an α2-adrenergic receptor agonist and it is commonly used in a form of eye drops to lower IOP in glaucoma patients. Recent studies have suggested that BMD has direct protective effects on RGCs involving IOP-independent mechanisms, but it is still controversial. In the present study, we examined the effects of BMD in EAAC1-deficient (KO) mice, an animal model of normal tension glaucoma. BMD caused a small decrease in IOP, but sequential in vivo retinal imaging and electrophysiological analysis revealed that treatment with BMD was highly effective for RGC protection in EAAC1 KO mice. BMD suppressed the phosphorylation of the N-methyl-D-aspartate receptor 2B (NR2B) subunit in RGCs in EAAC1 KO mice. Furthermore, in cultured Müller glia, BMD stimulated the production of several neurotrophic factors that enhance RGC survival. These results suggest that, in addition to lowering IOP, BMD prevents glaucomatous retinal degeneration by stimulating multiple pathways including glia–neuron interactions. | |||||||||||||||||||||
| 書誌情報 |
en : Cell Death & Disease 巻 5, p. e1341, 発行日 2014-07-17 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 20414889 | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||
| 権利情報 | Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ | |||||||||||||||||||||
| EID | ||||||||||||||||||||||
| 識別子 | 281375 | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
