| Item type |
文献 / Documents(1) |
| 公開日 |
2025-02-21 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/ijms25010573 |
|
|
関連名称 |
10.3390/ijms25010573 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
The Utility of Urinary Titin to Diagnose and Predict the Prognosis of Acute Myocardial Infarction |
| 著者 |
Arase, Miharu
Nakanishi, Nobuto
堤, 理恵
Kawakami, Ayuka
新井, 悠太
阪上, 浩
大藤, 純
|
| 抄録 |
|
|
内容記述 |
Early detection and management are crucial for better prognosis in acute myocardial infarction (AMI). Serum titin, a component of the sarcomere in cardiac and skeletal muscle, was associated with AMI. Thus, we hypothesized that urinary N-fragment titin may be a biomarker for its diagnosis and prognosis. Between January 2021 and November 2021, we prospectively enrolled 83 patients with suspected AMI. Their urinary N-fragment titin, serum high-sensitivity troponin I (hsTnI), creatine kinase (CK), and creatine kinase-MB (CK-MB) were measured on admission. Then, urinary titin was assessed as diagnostic and prognostic biomarker in AMI. Among 83 enrolled patients, 51 patients were diagnosed as AMI. In AMI patients who were admitted as early as 3 h or longer after symptom onset, their urinary titin levels were significantly higher than non-AMI patients who are also admitted 3 h or longer after symptom onset (12.76 [IQR 5.87–16.68] pmol/mgCr (creatinine) and 5.13 [IQR 3.93–11.25] pmol/mgCr, p = 0.045, respectively). Moreover, the urinary titin levels in patients who died during hospitalization were incredibly higher than in those who were discharged (15.90 [IQR 13.46–22.61] pmol/mgCr and 4.90 [IQR 3.55–11.95] pmol/mgCr, p = 0.023). Urinary N-fragment titin can be used as non-invasive early diagnostic biomarker in AMI. Furthermore, it associates with hospital discharge disposition, providing prognostic utility. |
| キーワード |
|
|
主題 |
acute myocardial infarction |
| キーワード |
|
|
主題 |
urinary titin |
| キーワード |
|
|
主題 |
muscle |
| 書誌情報 |
International Journal of Molecular Sciences
巻 25,
号 1,
p. 573,
発行日 2024-01-01
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
14220067 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
407999 |
| 言語 |
|
|
言語 |
eng |
ijms_25_1_573.pdf (1.3 MB)
.png)
