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Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70
https://tokushima-u.repo.nii.ac.jp/records/2000315
https://tokushima-u.repo.nii.ac.jp/records/2000315a4e36635-b5d3-4f1e-a96c-6c26a9ab493f
| 名前 / ファイル | ライセンス | アクション |
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cdd_5_e1027.pdf (1.2 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||
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| 公開日 | 2025-02-27 | |||||||||||||||
| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版社版DOI | ||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/cddis.2013.550 | |||||||||||||||
| 関連名称 | 10.1038/cddis.2013.550 | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70 | |||||||||||||||
| タイトル別表記 | ||||||||||||||||
| その他のタイトル | Ibuprofen and cisplatin-mediated apoptosis | |||||||||||||||
| 著者 |
Endo, H
× Endo, H
× Yano, M
× 奥村, 裕司× 木戸, 博
WEKO
173
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| 内容記述 | Hsp70 is often overexpressed in cancer cells, and the selective cellular survival advantage that it confers may contribute to the process of tumour formation. Thus, the pharmacological manipulation of Hsp70 levels in cancer cells may be an effective means of preventing the progression of tumours. We found that the downregulation of Hsp70 by ibuprofen in vitro enhances the antitumoural activity of cisplatin in lung cancer. Ibuprofen prominently suppressed the expression of Hsp70 in A549 cells derived from lung adenocarcinoma and sensitized them to cisplatin in association with an increase in the mitochondrial apoptotic cascade, whereas ibuprofen alone did not induce cell death. The cisplatin-dependent events occurring up- and downstream of mitochondrial disruption were accelerated by treatment with ibuprofen. The increase in cisplatin-induced apoptosis caused by the depletion of Hsp70 by RNA interference is evidence that the increased apoptosis by ibuprofen is mediated by its effect on Hsp70. Our observations indicate that the suppression of Hsp70 by ibuprofen mediates the sensitivity to cisplatin by enhancing apoptosis at several stages of the mitochondrial cascade. Ibuprofen, therefore, is a potential therapeutic agent that might allow lowering the doses of cisplatin and limiting the many challenge associated with its toxicity and development of drug resistance. | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | Hsp70 | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | apoptosis | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | ibuprofen | |||||||||||||||
| 書誌情報 |
en : Cell Death and Disease 巻 5, p. e1027, 発行日 2014-01-30 |
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| 収録物ID | ||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 20414889 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||
| 権利情報 | ||||||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. | |||||||||||||||
| EID | ||||||||||||||||
| 識別子 | 307919 | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
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Endo, H, Yano, M, 奥村, 裕司, 木戸, 博, 2014, Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70: Springer Nature, e1027– p.
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