| Item type |
文献 / Documents(1) |
| 公開日 |
2025-02-21 |
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/ijms242316567 |
|
|
関連名称 |
10.3390/ijms242316567 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals |
| 著者 |
岩佐, 武
Noguchi, Hiroki
Tanano, Risa
Yamanaka, Erika
武田, 明日香
田村, 公
Aoki, Hidenori
Sugimoto, Tatsuro
Sasada, Hikari
Maeda,Takaaki
湊, 沙希
Yamamoto, Shota
乾, 宏彰
香川, 智洋
吉田, あつ子
峯田, あゆか
新居, 真理
木内, 理世
吉田, 加奈子
山本, 由理
加地, 剛
|
| 抄録 |
|
|
内容記述 |
In recent years, the effects of androgens on metabolic and body weight regulation systems and their underlying mechanisms have been gradually revealed in females. In women and experimental animals of reproductive age, androgen excess can adversely affect metabolic functioning, appetite, and body weight regulation. In addition, excess androgens can increase the risk of metabolic disorders, such as obesity, insulin resistance, and diabetes. These unfavorable effects of androgens are induced by alterations in the actions of hypothalamic appetite-regulatory factors, reductions in energy expenditure, insulin resistance in skeletal muscle, and β-cell dysfunction. Interestingly, these unfavorable effects of androgens on metabolic and body-weight regulation systems are neither observed nor evident in ovariectomized animals and post-menopausal women, indicating that the adverse effects of androgens might be dependent on the estrogen milieu. Recent findings may provide novel sex- and age-specific strategies for treating metabolic diseases. |
| キーワード |
|
|
主題 |
androgen |
| キーワード |
|
|
主題 |
estrogen |
| キーワード |
|
|
主題 |
PCOS |
| キーワード |
|
|
主題 |
hypothalamus |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 24,
号 23,
p. 16567,
発行日 2023-11-21
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
14220067 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
408078 |
| 言語 |
|
|
言語 |
eng |
ijms_24_23_16567.pdf (500 KB)
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