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An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system
https://tokushima-u.repo.nii.ac.jp/records/2000332
https://tokushima-u.repo.nii.ac.jp/records/20003327f56d475-f0af-451e-93ea-f5f9b05e9601
| 名前 / ファイル | ライセンス | アクション |
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srep_4_4335.pdf (1.6 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||
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| 公開日 | 2025-03-04 | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/srep04335 | |||||||||||||||||||||
| 関連名称 | 10.1038/srep04335 | |||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system | |||||||||||||||||||||
| 著者 |
Yoshida, Hiroshi
× Yoshida, Hiroshi
× Bando, Tetsuya
× 三戸, 太郎
WEKO
123
× 大内, 淑代× 野地, 澄晴
WEKO
120
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| 内容記述 | What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended the model as a means of interpreting experimental results in cricket leg regeneration. We assumed that (1) Ds/Ft trans-heterodimers or trans-homodimers are redistributed during cell division and (2) growth would cease when a differential of the dimer across each cell decreases to a certain threshold. We applied our model to simulate the results obtained by leg regeneration experiments in a cricket model. The results were qualitatively consistent with the experimental data obtained for cricket legs by RNA interference methodology. Using our extended steepness model, we provided a molecular-based explanation for leg size determination even in intercalary regeneration and for organ size determination. | |||||||||||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 4, p. 4335, 発行日 2014-03-11 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||||||||||
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| 出版者 | Springer Nature | |||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ | |||||||||||||||||||||
| EID | ||||||||||||||||||||||
| 識別子 | 292725 | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
