| Item type |
文献 / Documents(1) |
| 公開日 |
2011-12-02 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Inhibitory effects of bitter melon (Momordica charantia Linn.) on bacterial mutagenesis and aberrant crypt focus formation in the rat colon |
|
言語 |
en |
| 著者 |
Chiampanichayakul, Sawitree
片岡, 佳子
有持, 秀喜
Thumvijit, Somsakul
桑原, 知巳
中山, 治之
Vinitketkumnuen, Usanee
大西, 克成
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Antimutagenicity and chemopreventive activity of an 80%-ethanol extract of bitter melon (Momordica charantia Linn.) against the formation of azoxymethane (AOM)-induced aberrant crypt foci (ACF) was investigated. The bitter melon extract was nonmutagenic and inhibited the mutagenicity of heterocyclic amines 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and aflatoxin B1 in the Salmonella mutation assay. To examine the inhibitory effect of bitter melon on AOM-induced ACF formation, male F344 rats were fed various concentrations of the extract (0.1, 0.5, and 1.0 g/kg body weight) for five weeks during the initiation stage. One week after the administration of the plant extract, rats were subcutaneously given AOM at 15 mg/kg body weight once a week for two weeks. Three rats in each group were sacrificed 12 hr after the second AOM injection to analyze DNA adducts, O6-methylguanine (O6-meG) and N7-methylguanine in the liver and colon. The remaining rats were sacrificed 3 weeks after the second AOM injection to observe ACF. To examine the inhibitory effect of the extract on ACF formation in the postinitiation stage, rats were fed the extract at 0.1 and 1.0 g/kg body weight for 12 weeks starting two weeks after the second AOM injection. Treatment with bitter melon extract significantly inhibited ACF formation in the colon during the initiation stage and dose-dependently decreased the average of O6-meG DNA adduct in the colonic mucosa. During the postinitiation stage, bitter melon extract, at 1.0 g/kg body weight, significantly inhibited ACF formation in the colon, especially the formation of ACF with four or more crypts per focus. These findings suggest that bitter melon is a possible chemopreventive agent against colon carcinogenesis. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bitter melon |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Momordica charantia Linn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
antimutagenicity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
azoxymethane-induced aberrant crypt foci |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
O6-methylguanine |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 48,
号 1-2,
p. 88-96,
発行日 2001
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 備考 |
|
|
言語 |
ja |
|
値 |
データ元 : http://medical.med.tokushima-u.ac.jp/jmi/ |
| EID |
|
|
識別子 |
127943 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
LID201112022005.pdf (212 KB)
