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Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease
https://tokushima-u.repo.nii.ac.jp/records/2001006
https://tokushima-u.repo.nii.ac.jp/records/2001006eadda6de-2f27-4b9f-9547-b139bd18279d
名前 / ファイル | ライセンス | アクション |
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Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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公開日 | 2011-12-01 | |||||||||||||||||||||||
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アクセス権 | open access | |||||||||||||||||||||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
資源タイプ | journal article | |||||||||||||||||||||||
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出版タイプ | VoR | |||||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
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タイトル | Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease | |||||||||||||||||||||||
著者 |
吉栖, 正典
× 吉栖, 正典
× 土屋, 浩一郎
WEKO
1567
× 玉置, 俊晃
WEKO
168
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内容記述 | Reactive oxygen species (ROS), generated by reduction-oxidation (redox) reactions, have been recognized as important chemical mediators that regulate signal transduction. It has been reported that increase in ROS generation may relate to a risk for cardiovascular diseases such as atherosclerosis, angina pectoris, and myocardial infarction. Therefore, understanding the ROS-generating biological processes and ROS-induced intracellular signaling will be informative to gain insights into the pathogenesis of these diseases. In this review, we focus on the sources and reactions of ROS in the cardiovascular system and the role of mitogen-activated protein (MAP) kinase pathway in redox-mediated signal transduction. Clinical implications of ROS and MAP kinase are then described to provide insight into the pathogenesis of various redox-sensitive cardiovascular diseases. The pathways responsible for ROS generation in the cardiovascular system may provide novel therapeutic targets. | |||||||||||||||||||||||
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主題 | reactive oxygen species | |||||||||||||||||||||||
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主題 | mitogen-activated protein kinase | |||||||||||||||||||||||
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主題 | signal transduction | |||||||||||||||||||||||
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主題 | cardiovascular disease | |||||||||||||||||||||||
書誌情報 |
en : The journal of medical investigation : JMI 巻 48, 号 1-2, p. 11-24, 発行日 2001 |
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収録物識別子タイプ | ISSN | |||||||||||||||||||||||
収録物識別子 | 13431420 | |||||||||||||||||||||||
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収録物識別子タイプ | NCID | |||||||||||||||||||||||
収録物識別子 | AA11166929 | |||||||||||||||||||||||
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値 | データ元 : http://medical.med.tokushima-u.ac.jp/jmi/ | |||||||||||||||||||||||
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識別子 | 131144 | |||||||||||||||||||||||
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言語 | eng |