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Protease-induced leukocyte chemotaxis and activation: roles in host defense and inflammation
https://tokushima-u.repo.nii.ac.jp/records/2001018
https://tokushima-u.repo.nii.ac.jp/records/20010181bce7501-da31-4541-a667-f862b2a7d960
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
LID201112052002.pdf (179 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2011-12-05 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Protease-induced leukocyte chemotaxis and activation: roles in host defense and inflammation | |||||||||||||||||||||||
| 著者 |
谷, 憲治
× 谷, 憲治× オオグシ, フミタカ
× シミズ, テルキ
× 曽根, 三郎
WEKO
1531
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| 内容記述 | The migration of leukocytes such as neutrophils, monocytes and lymphocytes into inflamed lesions is one of the critical events of inflammation. Although the traditional function of neutrophil-derived antimicrobial proteases is to ingest and kill bacteria, some neutrophil serine proteases have been shown to induce leukocyte migration and activation. Mast cell-derived chymase also has the chemotactic activity for leukocytes. During the acute phase of inflammatory and allergic diseases, the predominantly migrated cells are neutrophils and mast cells, respectively, and in the subsequent chronic phase, monocytes and lymphocytes are mainly migrated. The chemotactic activity for monocytes and lymphocytes of neutrophil-derived serine proteases and mast cell-derived chymase may have a role in switching acute inflammation to chronic inflammation and delayed-type hypersensitivity. Recently, aminopeptidase N and endothelin were shown to induce chemotactic migration of leukocyes. Thus, protease-induced leukocyte chemotaxis and activation may play an important role in immunologic events of inflammatory and allergic diseases. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | chemotaxis | |||||||||||||||||||||||
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| 主題 | leukocyte | |||||||||||||||||||||||
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| 主題 | thrombin | |||||||||||||||||||||||
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| 主題 | cathepsin G | |||||||||||||||||||||||
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| 主題 | chymase | |||||||||||||||||||||||
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| 主題 | endothelin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | aminopeptidase N | |||||||||||||||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 48, 号 3-4, p. 133-141, 発行日 2001 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||||||||
| 備考 | ||||||||||||||||||||||||
| 値 | データ元 : http://medical.med.tokushima-u.ac.jp/jmi/ | |||||||||||||||||||||||
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| 識別子 | 146481 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
