| Item type |
文献 / Documents(1) |
| 公開日 |
2011-12-09 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Protective effect of photodegradation product of nifedipine against tumor necrosis factor alpha-induced oxidative stress in human glomerular endothelial cells |
| 著者 |
フクハラ, ヤヨイ
土屋, 浩一郎
ホリノウチ, ユウヤ
タジマ, ソウイチロウ
木平, 孝高
濱野, 修一
川添, 和義
池田, 康将
石澤, 啓介
冨田, 修平
玉置, 俊晃
|
| 抄録 |
|
|
内容記述 |
Recently, increasing evidence suggests that the antihypertensive drug nifedipine acts as a protective agent for endothelial cells, and that the activity is unrelated to its calcium channel blocking. Nitrosonifedipine (NO-NIF) is metabolically and photochemically produced from nifedipine, and NO-NIF has been recognized as a contaminant of nifedipine because it has no antihypertensive effect. Treatment of tumor necrosis factor-α (TNF-α) suppressed the cell viability and facilitated the expression of Inter-Cellular Adhesion Molecule 1(ICAM-1) in human glomerular endothelial cells (HGECs) though, pretreatment of NO-NIF significantly recovered the TNF-α-induced cell damage to the same extent as Trolox-C did, and suppressed the ICAM-1 expression in a concentration dependent manner. In addition, NO-NIF inhibited the cell toxicity induced by cumene hydroperoxide, which hampers the integrity of cell membrane through oxidative stress, as effective as Trolox-c. These data suggest that NO-NIF is a candidate for a new class of antioxidative drug that protect cells against oxidative stress in glomerular endothelial cells. |
| キーワード |
|
|
主題 |
nifedipine |
| キーワード |
|
|
主題 |
nitrosonifedipine |
| キーワード |
|
|
主題 |
antioxidant |
| キーワード |
|
|
主題 |
tumor necrosis factor-α |
| キーワード |
|
|
主題 |
reactive oxygen species |
| キーワード |
|
|
主題 |
endothelial cells |
| キーワード |
|
|
主題 |
cumene hydroperoxide |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 58,
号 1-2,
p. 118-126,
発行日 2011-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 備考 |
|
|
値 |
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html |
| EID |
|
|
識別子 |
223410 |
| 言語 |
|
|
言語 |
eng |
LID201112092003.pdf (589 KB)
