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Analysis of DNA Extracted From the Trigeminal Ganglion Cells After Neonatal Capsaicin Treatment by Agarose Gel Electrophoresis
https://tokushima-u.repo.nii.ac.jp/records/2002043
https://tokushima-u.repo.nii.ac.jp/records/20020431447364b-4e8e-46d9-a07b-a8f97d43191e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
LID201211061001.pdf (164 KB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2012-12-17 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 関連識別子 | http://www.webmedcentral.com/article_view/3708 | |||||||||||
| 関連名称 | 10.9754/journal.wmc.2012.003708 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Analysis of DNA Extracted From the Trigeminal Ganglion Cells After Neonatal Capsaicin Treatment by Agarose Gel Electrophoresis | |||||||||||
| 著者 |
樋浦, 明夫
× 樋浦, 明夫× 中川, 弘
WEKO
1718
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| 抄録 | ||||||||||||
| 内容記述 | The aim of this study was to examine whether the neonatal injection of capsaicin induces DNA ladder formation, as an indicator of apoptosis, in the rat trigeminal ganglion (TG). The DNA extracted from the TGs after treatment with capsaicin (50 mg/kg) at 2 days of age exhibited diffuse DNA fragmentation instead of “ladder formation”, as determined by agarose gel electrophoresis. In contrast, clear DNA ladder formation was induced in human osteosarcoma cells treated with okadaic acid (OA) at concentrations of 10 and 20 nM. These results suggest that capsaicin cannot induce apoptosis of TG neurons sufficient for detectable DNA ladder formation. Thus, it is conceivable that capsaicin mainly causes necrosis rather than apoptosis in rodent primary sensory neurons. | |||||||||||
| キーワード | ||||||||||||
| 主題 | Capsaicin | |||||||||||
| キーワード | ||||||||||||
| 主題 | Aoptosis | |||||||||||
| キーワード | ||||||||||||
| 主題 | DNA ladder | |||||||||||
| キーワード | ||||||||||||
| 主題 | Okadaic acid | |||||||||||
| 書誌情報 |
en : WebmedCentral TOXICOLOGY 巻 3, 号 9, p. WMC003708, 発行日 2012-09-18 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 20461690 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | WebmedCentral | |||||||||||
| 備考 | ||||||||||||
| 値 | Article URL: http://www.webmedcentral.com/article_view/3708 | |||||||||||
| 権利情報 | ||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License(CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||
| EID | ||||||||||||
| 識別子 | 256955 | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
