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Participations of Glias and Immune Cells in Neuropathic Pain
https://tokushima-u.repo.nii.ac.jp/records/2002044
https://tokushima-u.repo.nii.ac.jp/records/2002044a52f6103-b735-4a45-8487-87fd80fa6298
| 名前 / ファイル | ライセンス | アクション |
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LID201211061002.pdf (163 KB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2012-12-17 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | http://www.webmedcentral.com/article_view/3728 | |||||||||||
| 言語 | ja | |||||||||||
| 関連名称 | 10.9754/journal.wmc.2012.003728 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Participations of Glias and Immune Cells in Neuropathic Pain | |||||||||||
| 言語 | en | |||||||||||
| 著者 |
樋浦, 明夫
× 樋浦, 明夫× 中川, 弘
WEKO
1718
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Nowadays, one cannot but recognize a key role of the peripheral and central glial cells for generation of clinical neuropathic pain. Many cytokines are released from glial cells, immune cells and nociceptive primary afferent central or peripheral terminals by injury, bacterial or viral infection, and envenomation by bee venom or scorpion. Released cytokines mutually affect by paracrine or autocrine manner among glias, immune cells and neurons, thereby produce and transmit the exaggerating pain information to the brain. Indeed, suppression of activated glia and immune cells by chemical agents or antibodies can relief abnormal pain caused by various experimental neuropathies. Thus, abnormal exaggerated pain cannot be explained without the role of glia and immune cells. Many investigators emphasized that therapeutic use of inactivating agents to glial and immune cells but not to neurons is available for alleviation of clinical pain. Thermo-TRP channels, TRPV1, TRPA1 and TRPM8 could not sense neuropathic pain by themselves without close interactions between glias, immune cells and TRP channels. The removal of persistent clinical pain will be rescued by treatment with inactivating chemicals to glias and immune cells. In addition, physiological noxious heat could be sensed by unknown sensor other than thermo-TRP channels, TRPV1, TRPA1 and TRPM8 | |||||||||||
| 言語 | en | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Glias | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | TRP channels | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Inflammatory soup | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Abnormal pain | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Acute noxious heat pain | |||||||||||
| 書誌情報 |
en : WebmedCentral PAIN 巻 3, 号 9, p. WMC003728, 発行日 2012-09-27 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 20461690 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | WebmedCentral | |||||||||||
| 言語 | en | |||||||||||
| 備考 | ||||||||||||
| 言語 | ja | |||||||||||
| 値 | Article URL: http://www.webmedcentral.com/article_view/3728 | |||||||||||
| 権利情報 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License(CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||
| EID | ||||||||||||
| 識別子 | 257215 | |||||||||||
| 識別子タイプ | URI | |||||||||||
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| 言語 | eng | |||||||||||
