| Item type |
文献 / Documents(1) |
| 公開日 |
2014-02-14 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats |
|
言語 |
en |
| 著者 |
ミヤケ, ケイコ
谷, 憲治
柿内, 聡司
スズカ, チユキ
豊田, 優子
岸, 潤
手塚, 敏史
湯浅, 志乃
埴淵, 昌毅
青野, 純典
西岡, 安彦
曽根, 三郎
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background : Gefitinib, an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has been reported to be associated with interstitial lung disorders, and their high incidence and mortality have become a matter of great concern, especially in Japan. In this study, we investigated the effect of gefitinib on different phases of radiationinduced lung disorders in an experimental model. Methods : The thoraxes of Wistar rats were irradiated on day 1 with a single X-ray dose of 20 Gy, and gefitinib (50 mg/kg/day) was orally administered from day 1 to 14. The rat lungs were harvested on days 15 and 57 and the bronchoalveolar lavage (BAL) was performed. Results : Gefitinib treatment increased the infiltration of inflammatory cells, which produced more pro-inflammatory cytokines (IL-6, IL-1β), in the lungs of the irradiated rats on days 15 and 57, while gefitinib treatment reduced collagen content of the lungs in irradiated rats and decreased proliferation and EGFR expression in the lung fibroblasts from irradiated rats on day 57. Conclusions : In irradiated rats, gefitinib treatment augmented lung inflammation, including inflammatory cell infiltration and pro-inflammatory cytokine expression, while gefitinib treatment attenuated fibrotic lung remodeling due to the inhibition of lung fibroblast proliferation. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gefitinib |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
radiation pneumonitis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
epidermal growth factor receptor |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 59,
号 1-2,
p. 174-185,
発行日 2012-02
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
251817 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
LID201402142004.pdf (1.15 MB)
