| Item type |
文献 / Documents(1) |
| 公開日 |
2014-02-26 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.60.21 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.60.21 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Mineralocorticoid receptor expression in human penile corpus cavernosum |
|
言語 |
en |
| 著者 |
キシモト, トモテル
布川, 朋也
山口, 邦久
山本, 恭代
ナカツジ, ヒロヨシ
井﨑, 博文
高橋, 正幸
福森, 知治
金山, 博臣
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Objectives : Mineralocorticoid receptor (MR) is known to play physiological and pathophysiological roles in the cardiovascular system, and MR activation directly damages these organs. The aim of this study was to evaluate the expression of MR and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in the human penile corpus cavernosum. Methods : MR and 11β-HSD2 expression was assayed in human penile tissues, and also in human renal tissues as a positive control. Expressions of MR mRNA and 11β-HSD2 mRNA were evaluated using reverse transcription polymerase chain reaction (RT-PCR). MR and 11β-HSD2 were visually identified using immunofluorescence analysis. Results : MR mRNA expression in human penis was confirmed by RT-PCR. On quantitative RT-PCR analysis, 11β-HSD2 mRNA expression was detected at minimal levels in penile tissue. Immunofluorescence analysis revealed positive staining for MR and negative staining for 11β-HSD2 in smooth muscle cells of the corpus cavernosum. Conclusions : This study demonstrated the presence of MR and the absence of 11β-HSD2 in human penile corpus cavernosum. Considering that MR activation causes various organ damages, MR blockade in human penile corpus cavernosum may have therapeutic benefits. Investigations for the penile effects of MR activation have the potential to provide new treatment approaches for erectile dysfunction. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
11-beta-hydroxysteroid dehydrogenase type 2 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
aldosterone |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
erectile dysfunction |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mineralocorticoid receptor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
penis |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 60,
号 1-2,
p. 21-26,
発行日 2013-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
284585 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
LID201402262002.pdf (596 KB)
