| Item type |
文献 / Documents(1) |
| 公開日 |
2015-07-29 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.2152/jmi.60.191 |
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関連名称 |
10.2152/jmi.60.191 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Hypercholesterolemia and effects of high cholesterol diet in type IIa sodium-dependent phosphate co-transporter (Npt2a) deficient mice |
| 著者 |
タナカ, サラサ
山本, 浩範
中橋, 乙起
イシグロ, マリコ
タケイ, ユウイチロウ
増田, 真志
香西, 美奈
イケダ, ショウコ
竹谷, 豊
宮本, 賢一
武田, 英二
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| 抄録 |
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内容記述 |
The type IIa sodium-dependent phosphate co-transporter (Npt2a) is important to maintain renal inorganic phosphate (Pi) homeostasis and the plasma Pi levels. It has reported that disorder of Pi metabolism in kidney can be risk factors for cardiovascular disease as well as hypercholesterolemia. However, the relationship between Pi and cholesterol metabolism has not been clarified. The current study investigated the effects of Npt2a gene ablation that is known as hypophosphatemia model on cholesterol metabolism in mice. Npt2a deficient (Npt2a-/-) mice and wild type mice were fed diets with or without 2% cholesterol for 12 days. Plasma lipid and lipoprotein profile analysis revealed that plasma lipid levels (total, LDL and HDL cholesterol) were significantly higher in Npt2a-/- mice than wild type (WT) mice. Interestingly, high cholesterol diet markedly increased plasma levels of total, LDL and HDL cholesterol in WT mice, but not Npt2a-/- mice. On the other hand, there were no differences in body and liver weight, intake and hepatic lipid accumulation between WT and Npt2a-/- mice. These results suggest that ablation of Npt2a gene induces hypercholesterolemia and affects the ability to respond normally to dietary cholesterol. |
| キーワード |
|
|
主題 |
Npt2a |
| キーワード |
|
|
主題 |
cholesterol |
| キーワード |
|
|
主題 |
hyperlipidemia |
| キーワード |
|
|
主題 |
hypophosphatemia |
| キーワード |
|
|
主題 |
mice |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 60,
号 3-4,
p. 191-196,
発行日 2013-08
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
284880 |
| 言語 |
|
|
言語 |
eng |
LID201507295003.pdf (272 KB)
