| Item type |
文献 / Documents(1) |
| 公開日 |
2015-08-06 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Immunohistochemical investigation of the coma blister and its pathogenesis |
|
言語 |
en |
| 著者 |
カシワギ, マサユキ
石上, 安希子
ハラ, ケンジ
マツスエ, アヤ
Waters, Brian
タカヤマ, ミオ
徳永, 逸夫
西村, 明儒
クボ, シンイチ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The erythematous patches and vesicles that are observed in coma patients, usually from an overdose of medication, are known as coma blisters. However, it is unknown whether the degenerated sweat gland is a necrosis or apoptosis. We immunohistochemically examined such skin lesions to investigate the characteristics and pathogenesis of the coma blister. Skin lesions were obtained from a forensic autopsy case, a woman in her thirties, of caffeine intoxication. Those lesions were observed in the left femoral, the lower left thigh, and the right knee. Histologically, the skin lesions showed that the keratinocytes had necrosed and the epidermis was thin in some areas. Eccrine sweat gland degeneration was observed. Obvious inflammatory cell infiltrations were not detected. Immunohistochemically, we stained each skin lesion against CD3, CD8, CD45RO, cytokeratin, 70 kD heat shock protein, ubiquitin, 150 kD oxygen regulated protein, and caspase-cleaved keratin 18 neo-epitope M30. They were also stained with an in situ apoptosis detection kit. Degenerated sweat glands featured CD45RO and M30 immunoreactivity. Immunohistochemical staining for CD45RO, CK-L, and M30 might be useful to observe sweat gland degeneration in the coma blister. Therefore, the apoptosis might be related to coma blisters and sweat gland degenerations. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
coma blister |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
sweat gland degeneration |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
apoptosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
intoxication |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
forensic autopsy cases |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 60,
号 3-4,
p. 256-261,
発行日 2013-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
284025 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
LID201508065002.pdf (652 KB)
