| Item type |
文献 / Documents(1) |
| 公開日 |
2015-06-10 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Nonivamide, a natural analog of capsaicin, affects intracellular Ca2+ level in rat thymic lymphocytes |
|
言語 |
en |
| 著者 |
サイトウ, ショウヘイ
フクナガ, エリ
ホンダ, サリ
金丸, 芳
佐藤, 征弥
小山, 保夫
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Effect of nonivamide, a natural analog of capsaicin, on intracellular Ca2+ level of rat thymocytes was examined using a flow-cytometric technique with appropriate fluorescent probes in order to further characterize the cytotoxicity because nonivamide can be used as an active intergradient of antifouling paints. Nonivamide at concentrations ranging from 30 μM to 300 μM significantly increased the intensity of Fluo-3 fluorescence. The potency of 100 μM nonivamide to increase the fluorescence was similar to that of 100 μM capsaicin. The increase in Fluo-3 fluorescence by 100 μM nonivamide was attenuated under an external Ca2+-free condition. Nonivamide at 100 μM also increased the intensity of Fluo-3 fluorescence in the continued presence of 100 μM capsaicin. It is suggested that nonivamide at high micromolar concentrations increases intracellular Ca2+ level via the activation of vanilloid receptors. Nonivamide concentrations (30 μM or more) that increase intracellular Ca2+ level in rat thymocytes are comparable to those in algal cells. However, it is something hard to argue the implications in environmental science because nonivamide doesn’t seem to be released into environment in such a high concentration, and because bioaccumulation of nonivamide has not been reported. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
nonivamide |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
intracellular Ca2+ |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lymphocyte |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
capsaicin |
| 書誌情報 |
ja : 徳島大学総合科学部自然科学研究 = Natural Science Research, The University of Tokushima
巻 28,
号 3,
p. 15-19,
発行日 2014-07
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09146385 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10065859 |
| EID |
|
|
識別子 |
280376 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
LID201506105003.pdf (724 KB)
