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Role of surfactant protein A in non-infectious lung diseases
https://tokushima-u.repo.nii.ac.jp/records/2002741
https://tokushima-u.repo.nii.ac.jp/records/2002741abf193f7-7b76-466f-b638-b359fdb2c538
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
LID201511195001.pdf (348 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2015-11-19 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Role of surfactant protein A in non-infectious lung diseases | |||||||||||||||||
| 著者 |
後東, 久嗣
× 後東, 久嗣× 三橋, 惇志
WEKO
969
× 西岡, 安彦
WEKO
1542
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| 抄録 | ||||||||||||||||||
| 内容記述 | Surfactant protein A (SP-A) is a large multimeric protein found in the airways and alveoli of the lungs. SP-A is a member of the collectin family of proteins, characterized by NH2-terminal collagen-like regions and COOH-terminal lectin domains. Although other surfactant proteins such as SP-B function to reduce surface tension in the lungs, SP-A as well as SP-D regulates the pulmonary immune response. To date, a number of studies have shown the immunoregulatory function of SP-A, mainly in the field of infectious diseases. By binding to a wide variety of pathogens, SP-A opsonizes and enhances pathogen uptake by phagocytes. In addition to the effect on pathogens, recent studies have shown that SP-A also modulates lung immune system in the area of non-infectious lung diseases. In this review, the potential role of SP-A in the multiple aspects of pulmonary host defense will be discussed, focusing mainly on non-infectious lung diseases such as acute and chronic pulmonary fibrosis and lung cancer. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | surfactant protein A | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | non-infectious lung injury | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | lung cancer | |||||||||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 61, 号 1-2, p. 1-6, 発行日 2014-02 |
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| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 299865 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
