| Item type |
文献 / Documents(1) |
| 公開日 |
2015-11-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.61.28 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.61.28 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Correlation of fibroblast growth factor 21 serum levels with metabolic parameters in Japanese subjects |
|
言語 |
en |
| 著者 |
Jin, Qing-Ri
坂東, 由記子
宮脇, 克行
シカマ, ヨウスケ
コスギ, チサト
アキ, ナナコ
船木, 真理
野地, 澄晴
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Objects : Since serum level of fibroblast growth factor 21 (FGF21) has been implicated as a potential biomarker for the early detection of the metabolic syndrome and type 2 diabetes, we examined how FGF21 serum levels are correlated with metabolic parameters in Japanese subjects. Methods : FGF21 levels were analyzed by enzyme-linked immunosorbent assays. Spearman’s correlation and multiple stepwise regression analyses were used to examine the relationship between serum FGF21 and other factors. A Mann-Whitney U test was performed between the normal and high groups for triglycerides and systolic blood pressure (BP) respectively. Results : By univariate correlation analysis, serum FGF21 levels were significantly associated with triglyceride levels, systolic BP, diastolic BP, pulse pressure, body mass index (BMI), age, fasting plasma glucose (FPG) levels, and total cholesterol levels. Multiple regression analysis (adjusted for age, gender, and BMI) showed that serum FGF21 levels were independently and significantly associated with triglyceride levels and systolic BP. Serum FGF21 levels were significantly higher in subjects with high triglyceride levels and high systolic BP compared with those who had normal triglyceride levels and normal systolic BP respectively. Conclusions : This study found that FGF21 levels might be a biomarker for some metabolic disorders associated with metabolic syndrome. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
FGF21 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
metabolic syndrome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
triglycerides |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
systolic BP |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
biomarker |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 61,
号 1-2,
p. 28-34,
発行日 2014-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
303101 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
LID201511195005.pdf (629 KB)
