| Item type |
文献 / Documents(1) |
| 公開日 |
2016-01-27 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effect of dietary components on renal inorganic phosphate (Pi) excretion induced by a Pi-depleted diet |
| 著者 |
オオニシ, リツコ
瀬川, 博子
オオモト, トモヨ
ササキ, ショウヘイ
ハナザキ, アイ
モリ, アヤカ
イクタ, カヨ
フルタニ, ジュンヤ
カワカミ, エリ
辰巳, 佐和子
濵田, 康弘
宮本, 賢一
|
| 抄録 |
|
|
内容記述 |
Dietary inorganic phosphate (Pi) is the most important factor in the regulation of renal Pi excretion. Recent studies suggest the presence of an enteric-renal signaling axis for dietary Pi as well as the existence of a mechanism by which the intestine detects changes in luminal Pi concentrations. The mechanisms of intestinal Pi sensing, however, are unknown. In the present study, we focused on Pi depletion signals and investigated the effects of dietary components on intestinal Pi sensing. After feeding rats experimental diets for 3 days, we investigated urinary Pi excretion and plasma biochemical parameters. Renal Pi excretion was suppressed in rats fed a low-Pi diet (0.02% Pi). Elimination of dietary calcium (Ca) completely blocked the suppression of Pi excretion, suggesting that the presence of Ca is essential for the Pi depletion signal. Furthermore, a minimum Ca content of more than 0.02% was necessary for the Pi depletion signal. Magnesium, lanthanum, and strontium, which are agonists of calcium sensing receptor, instead of Ca, reduced Pi excretion.Therefore, dietary Ca appears to be important for the Pi depletion-sensing mechanism in the gastrointestinal tract. In addition, the calcium sensing receptor may be involved in the Pi depletion signal. |
| キーワード |
|
|
主題 |
dietary phosphate |
| キーワード |
|
|
主題 |
sensing |
| キーワード |
|
|
主題 |
calcium |
| キーワード |
|
|
主題 |
phosphate excretion |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 61,
号 1-2,
p. 162-170,
発行日 2014-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
282998 |
| 言語 |
|
|
言語 |
eng |
LID201601275004.pdf (852 KB)
